The cytotoxic T lymphocyte immune synapse at a glance.
Journal of cell science
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Dieckmann, N. M., Frazer, G. L., Asano, Y., Stinchcombe, J., & Griffiths, G. (2016). The cytotoxic T lymphocyte immune synapse at a glance.. Journal of cell science, 129 (15), 2881-2886. https://doi.org/10.1242/jcs.186205
The immune synapse provides an important structure for communication with immune cells. Studies on immune synapses formed by cytotoxic T lymphocytes (CTLs) highlight the dynamic changes and specialised mechanisms required to facilitate focal signalling and polarised secretion in immune cells. In this Cell Science at a Glance article and the accompanying poster, we illustrate the different steps that reveal the specialised mechanisms used to focus secretion at the CTL immune synapse and allow CTLs to be such efficient and precise serial killers.
T-Lymphocytes, Cytotoxic, Cell Membrane, Cilia, Animals, Humans, Receptors, Antigen, T-Cell, Signal Transduction, Immunological Synapses
WELLCOME TRUST (103930/Z/14/Z)
Wellcome Trust (100140/Z/12/Z)
External DOI: https://doi.org/10.1242/jcs.186205
This record's URL: https://www.repository.cam.ac.uk/handle/1810/280746