The cytotoxic T lymphocyte immune synapse at a glance.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Dieckmann, Nele MG
Frazer, Gordon L
Asano, Yukako
Stinchcombe, Jane C
Griffiths, Gillian M https://orcid.org/0000-0003-0434-5842
Abstract
The immune synapse provides an important structure for communication with immune cells. Studies on immune synapses formed by cytotoxic T lymphocytes (CTLs) highlight the dynamic changes and specialised mechanisms required to facilitate focal signalling and polarised secretion in immune cells. In this Cell Science at a Glance article and the accompanying poster, we illustrate the different steps that reveal the specialised mechanisms used to focus secretion at the CTL immune synapse and allow CTLs to be such efficient and precise serial killers.
Description
Keywords
Cytotoxic T lymphocyte, Immune synapse, Secretion, Animals, Cell Membrane, Cilia, Humans, Immunological Synapses, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocytes, Cytotoxic
Journal Title
J Cell Sci
Conference Name
Journal ISSN
0021-9533
1477-9137
1477-9137
Volume Title
129
Publisher
The Company of Biologists
Publisher DOI
Sponsorship
Wellcome Trust (103930/Z/14/Z)
Wellcome Trust (100140/Z/12/Z)
Wellcome Trust (100140/Z/12/Z)