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dc.contributor.authorMartin, Jack L
dc.contributor.authorGruszczyk, Anja
dc.contributor.authorBeach, Tim
dc.contributor.authorMurphy, Mike
dc.contributor.authorSaeb-Parsy, Kourosh
dc.date.accessioned2018-09-27T14:09:14Z
dc.date.available2018-09-27T14:09:14Z
dc.date.issued2019-07
dc.identifier.issn0931-041X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/282771
dc.description.abstractAcute kidney injury (AKI) remains a major problem in critically unwell children and young adults. Ischaemia reperfusion (IR) injury is a major contributor to the development of AKI in a significant proportion of these cases and mitochondria are increasingly recognised as being central to this process through generation of a burst of reactive oxygen species early in reperfusion. Mitochondria have additionally been shown to have key roles in downstream processes including activation of the immune response, immunomodulation, and apoptosis and necrosis. The recognition of the central role of mitochondria in IR injury and an increased understanding of the pathophysiology that undermines these processes has resulted in identification of novel therapeutic targets and potential biomarkers. This review summarises a variety of therapeutic approaches that are currently under exploration and may have potential in ameliorating AKI in children in the future.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectKidney Tubules
dc.subjectMitochondria
dc.subjectHumans
dc.subjectReperfusion Injury
dc.subjectNecrosis
dc.subjectReactive Oxygen Species
dc.subjectDNA, Mitochondrial
dc.subjectAntioxidants
dc.subjectApoptosis
dc.subjectOxidative Stress
dc.subjectAcute Kidney Injury
dc.subjectBiomarkers
dc.subjectMitophagy
dc.titleMitochondrial mechanisms and therapeutics in ischaemia reperfusion injury.
dc.typeArticle
prism.endingPage1174
prism.issueIdentifier7
prism.publicationDate2019
prism.publicationNamePediatr Nephrol
prism.startingPage1167
prism.volume34
dc.identifier.doi10.17863/CAM.30135
dcterms.dateAccepted2018-05-09
rioxxterms.versionofrecord10.1007/s00467-018-3984-5
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-07
dc.contributor.orcidMurphy, Mike [0000-0003-1115-9618]
dc.contributor.orcidSaeb-Parsy, Kourosh [0000-0002-0633-3696]
dc.identifier.eissn1432-198X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/L017520/1)
pubs.funder-project-idMRC (1729420)
pubs.funder-project-idMedical Research Council (MC_UU_00015/3)
cam.issuedOnline2018-06-02


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International