Show simple item record

dc.contributor.authorElhakeem, Ahmed
dc.contributor.authorCooper, Rachel
dc.contributor.authorWhincup, Peter
dc.contributor.authorBrage, Soren
dc.contributor.authorKuh, Diana
dc.contributor.authorHardy, Rebecca
dc.date.accessioned2018-09-27T14:11:43Z
dc.date.available2018-09-27T14:11:43Z
dc.date.issued2018-08-21
dc.identifier.issn2047-9980
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/282829
dc.description.abstractBackground We examined associations of objectively measured physical activity ( PA ) and sedentary time with cardiovascular disease biomarkers at age 60 to 64 years. This included investigation of sex differences and the extent to which associations may be mediated by adiposity. Methods and Results Participants were 795 men and 827 women aged 60 to 64 years from the Medical Research Council National Survey of Health and Development. Combined heart rate and movement sensors worn for 5 consecutive days were used to derive overall PA energy expenditure, kJ /kg per day) and time spent sedentary (<1.5 metabolic equivalent of tasks), in light PA (1.5-3 metabolic equivalent of tasks) and moderate-to-vigorous intensity PA (>3 metabolic equivalent of tasks). Linear regression models were used to relate each PA parameter to inflammatory (C-reactive protein, interleukin-6), endothelial (tissue-plasminogen activator, E-selectin) and adipokine (leptin, adiponectin) markers extracted from fasting blood samples. Greater time in light PA and moderate-to-vigorous intensity PA and less sedentary time were associated with more favorable biomarker levels. For C-reactive protein, interleukin-6, and leptin, these differences were greater among women than men. For example, % differences (95% confidence intervals) in leptin for men and women per SD increases in sedentary time: 7.9 (2.7, 13.0) and 20.6 (15.3, 25.8); light intensity PA : -3.8 (-8.9, 12.7) and -17.7 (-23.1, -12.4), moderate-to-vigorous intensity PA : -12.9 (-17.9, -8.0) and -18.3 (-23.4, -13.1). Fat mass mediated a greater proportion of these associations in women than men. Conclusions Greater light PA and moderate-to-vigorous intensity PA and less sedentary time in early old age were associated with more favorable cardiovascular biomarker profiles. Fat mass partially mediated these associations but more strongly in women than men, which explained sex differences.
dc.description.sponsorshipThe MRC NSHD, RC, DK and RH are supported by the UK Medical Research Council [MC_UU_12019/1, MC_UU_12019/4 and G1001143]. SB is also supported by the UK Medical Research Council [MC_UU_12015/3].
dc.format.mediumPrint
dc.languageeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectCardiovascular Diseases
dc.subjectLeptin
dc.subjectTissue Plasminogen Activator
dc.subjectC-Reactive Protein
dc.subjectE-Selectin
dc.subjectInterleukin-6
dc.subjectExercise
dc.subjectLinear Models
dc.subjectEnergy Metabolism
dc.subjectTime Factors
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectAdiponectin
dc.subjectBiomarkers
dc.subjectSedentary Behavior
dc.titlePhysical Activity, Sedentary Time, and Cardiovascular Disease Biomarkers at Age 60 to 64 Years.
dc.typeArticle
prism.issueIdentifier16
prism.publicationDate2018
prism.publicationNameJ Am Heart Assoc
prism.startingPagee007459
prism.volume7
dc.identifier.doi10.17863/CAM.30193
dcterms.dateAccepted2018-06-13
rioxxterms.versionofrecord10.1161/JAHA.117.007459
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-08
dc.contributor.orcidBrage, Soren [0000-0002-1265-7355]
dc.identifier.eissn2047-9980
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_12015/3)


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International