Point-prevalence survey of carbapenemase-producing Enterobacteriaceae and vancomycin-resistant enterococci in adult inpatients in a university teaching hospital in the UK.
J Hosp Infect
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Wilson, H., Khokhar, F., Enoch, D., Brown, N., Ahluwalia, J., Dougan, G., & Török, M. (2018). Point-prevalence survey of carbapenemase-producing Enterobacteriaceae and vancomycin-resistant enterococci in adult inpatients in a university teaching hospital in the UK.. J Hosp Infect, 100 (1), 35-39. https://doi.org/10.1016/j.jhin.2018.06.024
Infections with carbapenemase-producing Enterobacteriaceae (CPE) and vancomycin-resistant enterococci (VRE) are associated with increased morbidity and mortality, but the carriage rates of CRE and VRE among hospital inpatients are unknown. A point-prevalence survey was conducted to determine CPE and VRE carriage rates in hospitalized adults. Eight hundred and eighteen of 960 (85.2%) adult inpatients were invited to participate in the study. Of these, 595 patients (72.7%) consented and provided specimens. Of 540 samples tested, none were positive for CPE. One hundred and thirty of 540 (24.1%) samples were VRE positive, and 34 of 40 (85%) of wards had cases. Universal screening for CPE may not be cost-effective in low-prevalence settings, but targeted screening of high-risk patients should continue. The optimal screening strategy for VRE remains to be determined, as universal screening and isolation is not feasible in the study setting.
Humans, Enterobacteriaceae Infections, Gram-Positive Bacterial Infections, Prevalence, Carrier State, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Inpatients, Hospitals, University, Female, Male, Young Adult, Vancomycin-Resistant Enterococci, Surveys and Questionnaires, United Kingdom, Carbapenem-Resistant Enterobacteriaceae
Academy of Medical Sciences (unknown)
Cambridge University Hospitals NHS Foundation Trust (CUH) (BRC)
Medical Research Council (MR/N029399/1)
External DOI: https://doi.org/10.1016/j.jhin.2018.06.024
This record's URL: https://www.repository.cam.ac.uk/handle/1810/282935
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/