Point-prevalence survey of carbapenemase-producing Enterobacteriaceae and vancomycin-resistant enterococci in adult inpatients in a university teaching hospital in the UK.
J Hosp Infect
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Wilson, H., Khokhar, F., Enoch, D., Brown, N., Ahluwalia, J., Dougan, G., & Török, M. (2018). Point-prevalence survey of carbapenemase-producing Enterobacteriaceae and vancomycin-resistant enterococci in adult inpatients in a university teaching hospital in the UK.. J Hosp Infect, 100 (1), 35-39. https://doi.org/10.1016/j.jhin.2018.06.024
Infections with carbapenemase-producing Enterobacteriaceae (CPE) and vancomycin-resistant enterococci (VRE) are associated with increased morbidity and mortality, but the carriage rates of CRE and VRE among hospital inpatients are unknown. A point-prevalence survey was conducted to determine CPE and VRE carriage rates in hospitalized adults. Eight hundred and eighteen of 960 (85.2%) adult inpatients were invited to participate in the study. Of these, 595 patients (72.7%) consented and provided specimens. Of 540 samples tested, none were positive for CPE. One hundred and thirty of 540 (24.1%) samples were VRE positive, and 34 of 40 (85%) of wards had cases. Universal screening for CPE may not be cost-effective in low-prevalence settings, but targeted screening of high-risk patients should continue. The optimal screening strategy for VRE remains to be determined, as universal screening and isolation is not feasible in the study setting.
CPE, Carriage, Prevalence, Surveillance, VRE, Adolescent, Adult, Aged, Aged, 80 and over, Carbapenem-Resistant Enterobacteriaceae, Carrier State, Enterobacteriaceae Infections, Female, Gram-Positive Bacterial Infections, Hospitals, University, Humans, Inpatients, Male, Middle Aged, Prevalence, Surveys and Questionnaires, United Kingdom, Vancomycin-Resistant Enterococci, Young Adult
Academy of Medical Sciences (unknown)
Cambridge University Hospitals NHS Foundation Trust (CUH) (BRC)
Medical Research Council (MR/N029399/1)
External DOI: https://doi.org/10.1016/j.jhin.2018.06.024
This record's URL: https://www.repository.cam.ac.uk/handle/1810/282935
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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