Increased Antielastase Activity in Idiopathic Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension.
Authors
Lodge, Katharine
Newnham, Michael
Bunclark, Katherine
Toshner, Mark
Publication Date
2018-11Journal Title
Am J Respir Cell Mol Biol
ISSN
1044-1549
Publisher
American Thoracic Society
Volume
59
Issue
5
Pages
652-655
Language
eng
Type
Article
Physical Medium
Print
Metadata
Show full item recordCitation
Guo, J., Lodge, K., Newnham, M., Bunclark, K., Toshner, M., Morrell, N. W., & Li, W. (2018). Increased Antielastase Activity in Idiopathic Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension.. Am J Respir Cell Mol Biol, 59 (5), 652-655. https://doi.org/10.1165/rcmb.2018-0060LE
Abstract
Pulmonary arterial hypertension (PAH) is characterized by abnormal remodeling and occlusion of pre-capillary arterioles in the lung with a subsequent increase in pulmonary vascular resistance. This can lead to right ventricular hypertrophy and ultimately right heart failure. Elastase is implicated in the pathobiology of PAH with evidence including: ultra-structural studies showing increased elastase activity in pulmonary arteries from children with congenital heart disease-associated PAH (1), increased elastase release from peripheral blood neutrophils isolated from patients with pulmonary hypertension compared with healthy controls (2) and elevated plasma concentrations of elastase in patients with idiopathic PAH (IPAH) (3).
Keywords
Pulmonary Artery, Humans, Thromboembolism, Chronic Disease, Leukocyte Elastase, alpha 1-Antitrypsin, Case-Control Studies, Middle Aged, Female, Male, Familial Primary Pulmonary Hypertension, Biomarkers
Sponsorship
British Heart Foundation (None)
British Heart Foundation (PG/15/39/31519)
British Heart Foundation (PG/17/1/32532)
British Heart Foundation (PG/17/58/33134)
British Heart Foundation (None)
Identifiers
External DOI: https://doi.org/10.1165/rcmb.2018-0060LE
This record's URL: https://www.repository.cam.ac.uk/handle/1810/282949
Rights
Licence:
http://www.rioxx.net/licenses/all-rights-reserved
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