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dc.contributor.authorGuo, Jingxu
dc.contributor.authorLodge, Katharine
dc.contributor.authorNewnham, Michael
dc.contributor.authorBunclark, Katherine
dc.contributor.authorToshner, Mark
dc.contributor.authorMorrell, Nicholas W
dc.contributor.authorLi, Wei
dc.date.accessioned2018-09-29T06:09:26Z
dc.date.available2018-09-29T06:09:26Z
dc.date.issued2018-11
dc.identifier.issn1044-1549
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/282949
dc.description.abstractPulmonary arterial hypertension (PAH) is characterized by abnormal remodeling and occlusion of pre-capillary arterioles in the lung with a subsequent increase in pulmonary vascular resistance. This can lead to right ventricular hypertrophy and ultimately right heart failure. Elastase is implicated in the pathobiology of PAH with evidence including: ultra-structural studies showing increased elastase activity in pulmonary arteries from children with congenital heart disease-associated PAH (1), increased elastase release from peripheral blood neutrophils isolated from patients with pulmonary hypertension compared with healthy controls (2) and elevated plasma concentrations of elastase in patients with idiopathic PAH (IPAH) (3).
dc.format.mediumPrint
dc.languageeng
dc.publisherAmerican Thoracic Society
dc.subjectPulmonary Artery
dc.subjectHumans
dc.subjectThromboembolism
dc.subjectChronic Disease
dc.subjectLeukocyte Elastase
dc.subjectalpha 1-Antitrypsin
dc.subjectCase-Control Studies
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectFamilial Primary Pulmonary Hypertension
dc.subjectBiomarkers
dc.titleIncreased Antielastase Activity in Idiopathic Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension.
dc.typeArticle
prism.endingPage655
prism.issueIdentifier5
prism.publicationDate2018
prism.publicationNameAm J Respir Cell Mol Biol
prism.startingPage652
prism.volume59
dc.identifier.doi10.17863/CAM.30312
dcterms.dateAccepted2018-07-11
rioxxterms.versionofrecord10.1165/rcmb.2018-0060LE
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-11
dc.contributor.orcidGuo, Jingxu [0000-0002-1568-4842]
dc.contributor.orcidMorrell, Nicholas W [0000-0001-5700-9792]
dc.contributor.orcidLi, Wei [0000-0002-1924-3120]
dc.identifier.eissn1535-4989
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idBritish Heart Foundation (PG/15/39/31519)
pubs.funder-project-idBritish Heart Foundation (PG/17/1/32532)
pubs.funder-project-idBritish Heart Foundation (PG/17/58/33134)
pubs.funder-project-idBritish Heart Foundation (None)


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