Show simple item record

dc.contributor.authorHolmes, Michael V
dc.contributor.authorDale, Caroline E
dc.contributor.authorZuccolo, Luisa
dc.contributor.authorSilverwood, Richard J
dc.contributor.authorGuo, Yiran
dc.contributor.authorYe, Zheng
dc.contributor.authorPrieto-Merino, David
dc.contributor.authorDehghan, Abbas
dc.contributor.authorTrompet, Stella
dc.contributor.authorWong, Andrew
dc.contributor.authorCavadino, Alana
dc.contributor.authorDrogan, Dagmar
dc.contributor.authorPadmanabhan, Sandosh
dc.contributor.authorLi, Shanshan
dc.contributor.authorYesupriya, Ajay
dc.contributor.authorLeusink, Maarten
dc.contributor.authorSundstrom, Johan
dc.contributor.authorHubacek, Jaroslav A
dc.contributor.authorPikhart, Hynek
dc.contributor.authorSwerdlow, Daniel I
dc.contributor.authorPanayiotou, Andrie G
dc.contributor.authorBorinskaya, Svetlana A
dc.contributor.authorFinan, Chris
dc.contributor.authorShah, Sonia
dc.contributor.authorKuchenbaecker, Karoline
dc.contributor.authorShah, Tina
dc.contributor.authorEngmann, Jorgen
dc.contributor.authorFolkersen, Lasse
dc.contributor.authorEriksson, Per
dc.contributor.authorRicceri, Fulvio
dc.contributor.authorMelander, Olle
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorGamble, Dale M
dc.contributor.authorRayaprolu, Sruti
dc.contributor.authorRoss, Owen A
dc.contributor.authorMcLachlan, Stela
dc.contributor.authorVikhireva, Olga
dc.contributor.authorSluijs, Ivonne
dc.contributor.authorScott, Robert
dc.contributor.authorAdamkova, Vera
dc.contributor.authorFlicker, Leon
dc.contributor.authorBockxmeer, Frank M van
dc.contributor.authorPower, Christine
dc.contributor.authorMarques-Vidal, Pedro
dc.contributor.authorMeade, Tom
dc.contributor.authorMarmot, Michael G
dc.contributor.authorFerro, Jose M
dc.contributor.authorPaulos-Pinheiro, Sofia
dc.contributor.authorHumphries, Steve E
dc.contributor.authorTalmud, Philippa J
dc.contributor.authorMateo Leach, Irene
dc.contributor.authorVerweij, Niek
dc.contributor.authorLinneberg, Allan
dc.contributor.authorSkaaby, Tea
dc.contributor.authorDoevendans, Pieter A
dc.contributor.authorCramer, Maarten J
dc.contributor.authorvan der Harst, Pim
dc.contributor.authorKlungel, Olaf H
dc.contributor.authorDowling, Nicole F
dc.contributor.authorDominiczak, Anna F
dc.contributor.authorKumari, Meena
dc.contributor.authorNicolaides, Andrew N
dc.contributor.authorWeikert, Cornelia
dc.contributor.authorBoeing, Heiner
dc.contributor.authorEbrahim, Shah
dc.contributor.authorGaunt, Tom R
dc.contributor.authorPrice, Jackie F
dc.contributor.authorLannfelt, Lars
dc.contributor.authorPeasey, Anne
dc.contributor.authorKubinova, Ruzena
dc.contributor.authorPajak, Andrzej
dc.contributor.authorMalyutina, Sofia
dc.contributor.authorVoevoda, Mikhail I
dc.contributor.authorTamosiunas, Abdonas
dc.contributor.authorMaitland-van der Zee, Anke H
dc.contributor.authorNorman, Paul E
dc.contributor.authorHankey, Graeme J
dc.contributor.authorBergmann, Manuela M
dc.contributor.authorHofman, Albert
dc.contributor.authorFranco, Oscar H
dc.contributor.authorCooper, Jackie
dc.contributor.authorPalmen, Jutta
dc.contributor.authorSpiering, Wilko
dc.contributor.authorde Jong, Pim A
dc.contributor.authorKuh, Diana
dc.contributor.authorHardy, Rebecca
dc.contributor.authorUitterlinden, Andre G
dc.contributor.authorIkram, M Arfan
dc.contributor.authorFord, Ian
dc.contributor.authorHyppönen, Elina
dc.contributor.authorAlmeida, Osvaldo P
dc.contributor.authorWareham, Nicholas
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorHamsten, Anders
dc.contributor.authorHusemoen, Lise Lotte N
dc.contributor.authorTjønneland, Anne
dc.contributor.authorTolstrup, Janne S
dc.contributor.authorRimm, Eric
dc.contributor.authorBeulens, Joline WJ
dc.contributor.authorVerschuren, WM Monique
dc.contributor.authorOnland-Moret, N Charlotte
dc.contributor.authorHofker, Marten H
dc.contributor.authorWannamethee, S Goya
dc.contributor.authorWhincup, Peter H
dc.contributor.authorMorris, Richard
dc.contributor.authorVicente, Astrid M
dc.contributor.authorWatkins, Hugh
dc.contributor.authorFarrall, Martin
dc.contributor.authorJukema, J Wouter
dc.contributor.authorMeschia, James
dc.contributor.authorCupples, L Adrienne
dc.contributor.authorSharp, Stephen
dc.contributor.authorFornage, Myriam
dc.contributor.authorKooperberg, Charles
dc.contributor.authorLaCroix, Andrea Z
dc.contributor.authorDai, James Y
dc.contributor.authorLanktree, Matthew B
dc.contributor.authorSiscovick, David S
dc.contributor.authorJorgenson, Eric
dc.contributor.authorSpring, Bonnie
dc.contributor.authorCoresh, Josef
dc.contributor.authorLi, Yun R
dc.contributor.authorBuxbaum, Sarah G
dc.contributor.authorSchreiner, Pamela J
dc.contributor.authorEllison, R Curtis
dc.contributor.authorTsai, Michael Y
dc.contributor.authorPatel, Sanjay R
dc.contributor.authorRedline, Susan
dc.contributor.authorJohnson, Andrew D
dc.contributor.authorHoogeveen, Ron C
dc.contributor.authorHakonarson, Hakon
dc.contributor.authorRotter, Jerome I
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorde Bakker, Paul IW
dc.contributor.authorKivimaki, Mika
dc.contributor.authorAsselbergs, Folkert W
dc.contributor.authorSattar, Naveed
dc.contributor.authorLawlor, Debbie A
dc.contributor.authorWhittaker, John
dc.contributor.authorDavey Smith, George
dc.contributor.authorMukamal, Kenneth
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorWilson, James G
dc.contributor.authorLange, Leslie A
dc.contributor.authorHamidovic, Ajna
dc.contributor.authorHingorani, Aroon D
dc.contributor.authorNordestgaard, Børge G
dc.contributor.authorBobak, Martin
dc.contributor.authorLeon, David A
dc.contributor.authorLangenberg, Claudia
dc.contributor.authorPalmer, Tom M
dc.contributor.authorReiner, Alex P
dc.contributor.authorKeating, Brendan J
dc.contributor.authorDudbridge, Frank
dc.contributor.authorCasas, Juan P
dc.contributor.authorInterAct Consortium
dc.date.accessioned2018-09-29T06:10:08Z
dc.date.available2018-09-29T06:10:08Z
dc.date.issued2014-07-10
dc.identifier.issn1756-1833
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/282974
dc.description.abstractOBJECTIVE: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN: Mendelian randomisation meta-analysis of 56 epidemiological studies. PARTICIPANTS: 261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers. MAIN OUTCOME MEASURES: Odds ratio for coronary heart disease and stroke associated with the ADH1B variant in all individuals and by categories of alcohol consumption. RESULTS: Carriers of the A-allele of ADH1B rs1229984 consumed 17.2% fewer units of alcohol per week (95% confidence interval 15.6% to 18.9%), had a lower prevalence of binge drinking (odds ratio 0.78 (95% CI 0.73 to 0.84)), and had higher abstention (odds ratio 1.27 (1.21 to 1.34)) than non-carriers. Rs1229984 A-allele carriers had lower systolic blood pressure (-0.88 (-1.19 to -0.56) mm Hg), interleukin-6 levels (-5.2% (-7.8 to -2.4%)), waist circumference (-0.3 (-0.6 to -0.1) cm), and body mass index (-0.17 (-0.24 to -0.10) kg/m(2)). Rs1229984 A-allele carriers had lower odds of coronary heart disease (odds ratio 0.90 (0.84 to 0.96)). The protective association of the ADH1B rs1229984 A-allele variant remained the same across all categories of alcohol consumption (P=0.83 for heterogeneity). Although no association of rs1229984 was identified with the combined subtypes of stroke, carriers of the A-allele had lower odds of ischaemic stroke (odds ratio 0.83 (0.72 to 0.95)). CONCLUSIONS: Individuals with a genetic variant associated with non-drinking and lower alcohol consumption had a more favourable cardiovascular profile and a reduced risk of coronary heart disease than those without the genetic variant. This suggests that reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health.
dc.format.mediumElectronic
dc.languageeng
dc.publisherBMJ
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectInterAct Consortium
dc.subjectHumans
dc.subjectCoronary Disease
dc.subjectAlcohol Dehydrogenase
dc.subjectGenetic Markers
dc.subjectModels, Statistical
dc.subjectAlcohol Drinking
dc.subjectGenotype
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectStroke
dc.subjectMendelian Randomization Analysis
dc.subjectBiomarkers
dc.titleAssociation between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.
dc.typeArticle
prism.publicationDate2014
prism.publicationNameBMJ
prism.startingPageg4164
prism.volume349
dc.identifier.doi10.17863/CAM.30336
dcterms.dateAccepted2014-05-21
rioxxterms.versionofrecord10.1136/bmj.g4164
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2014-07-10
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidKhaw, Kay-Tee [0000-0002-8802-2903]
dc.contributor.orcidSharp, Stephen [0000-0003-2375-1440]
dc.contributor.orcidLangenberg, Claudia [0000-0002-5017-7344]
dc.identifier.eissn1756-1833
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (G1000143)
pubs.funder-project-idMedical Research Council (MC_UU_12015/1)
pubs.funder-project-idNational Institute of Diabetes and Digestive and Kidney Diseases (U01DK062418)
pubs.funder-project-idMedical Research Council (G0701863)
pubs.funder-project-idEconomic and Social Research Council (ES/I025561/2)
pubs.funder-project-idMedical Research Council (G0401527)
pubs.funder-project-idMedical Research Council (MC_U106179471)
cam.issuedOnline2014-07-10


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International