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dc.contributor.authorHolmes, Michael Ven
dc.contributor.authorDale, Caroline Een
dc.contributor.authorZuccolo, Luisaen
dc.contributor.authorSilverwood, Richard Jen
dc.contributor.authorGuo, Yiranen
dc.contributor.authorYe, Zhengen
dc.contributor.authorPrieto-Merino, Daviden
dc.contributor.authorDehghan, Abbasen
dc.contributor.authorTrompet, Stellaen
dc.contributor.authorWong, Andrewen
dc.contributor.authorCavadino, Alanaen
dc.contributor.authorDrogan, Dagmaren
dc.contributor.authorPadmanabhan, Sandoshen
dc.contributor.authorLi, Shanshanen
dc.contributor.authorYesupriya, Ajayen
dc.contributor.authorLeusink, Maartenen
dc.contributor.authorSundstrom, Johanen
dc.contributor.authorHubacek, Jaroslav Aen
dc.contributor.authorPikhart, Hyneken
dc.contributor.authorSwerdlow, Daniel Ien
dc.contributor.authorPanayiotou, Andrie Gen
dc.contributor.authorBorinskaya, Svetlana Aen
dc.contributor.authorFinan, Chrisen
dc.contributor.authorShah, Soniaen
dc.contributor.authorKuchenbaecker, Karolineen
dc.contributor.authorShah, Tinaen
dc.contributor.authorEngmann, Jorgenen
dc.contributor.authorFolkersen, Lasseen
dc.contributor.authorEriksson, Peren
dc.contributor.authorRicceri, Fulvioen
dc.contributor.authorMelander, Olleen
dc.contributor.authorSacerdote, Carlottaen
dc.contributor.authorGamble, Dale Men
dc.contributor.authorRayaprolu, Srutien
dc.contributor.authorRoss, Owen Aen
dc.contributor.authorMcLachlan, Stelaen
dc.contributor.authorVikhireva, Olgaen
dc.contributor.authorSluijs, Ivonneen
dc.contributor.authorScott, Roberten
dc.contributor.authorAdamkova, Veraen
dc.contributor.authorFlicker, Leonen
dc.contributor.authorBockxmeer, Frank M vanen
dc.contributor.authorPower, Christineen
dc.contributor.authorMarques-Vidal, Pedroen
dc.contributor.authorMeade, Tomen
dc.contributor.authorMarmot, Michael Gen
dc.contributor.authorFerro, Jose Men
dc.contributor.authorPaulos-Pinheiro, Sofiaen
dc.contributor.authorHumphries, Steve Een
dc.contributor.authorTalmud, Philippa Jen
dc.contributor.authorMateo Leach, Ireneen
dc.contributor.authorVerweij, Nieken
dc.contributor.authorLinneberg, Allanen
dc.contributor.authorSkaaby, Teaen
dc.contributor.authorDoevendans, Pieter Aen
dc.contributor.authorCramer, Maarten Jen
dc.contributor.authorvan der Harst, Pimen
dc.contributor.authorKlungel, Olaf Hen
dc.contributor.authorDowling, Nicole Fen
dc.contributor.authorDominiczak, Anna Fen
dc.contributor.authorKumari, Meenaen
dc.contributor.authorNicolaides, Andrew Nen
dc.contributor.authorWeikert, Corneliaen
dc.contributor.authorBoeing, Heineren
dc.contributor.authorEbrahim, Shahen
dc.contributor.authorGaunt, Tom Ren
dc.contributor.authorPrice, Jackie Fen
dc.contributor.authorLannfelt, Larsen
dc.contributor.authorPeasey, Anneen
dc.contributor.authorKubinova, Ruzenaen
dc.contributor.authorPajak, Andrzejen
dc.contributor.authorMalyutina, Sofiaen
dc.contributor.authorVoevoda, Mikhail Ien
dc.contributor.authorTamosiunas, Abdonasen
dc.contributor.authorMaitland-van der Zee, Anke Hen
dc.contributor.authorNorman, Paul Een
dc.contributor.authorHankey, Graeme Jen
dc.contributor.authorBergmann, Manuela Men
dc.contributor.authorHofman, Alberten
dc.contributor.authorFranco, Oscar Hen
dc.contributor.authorCooper, Jackieen
dc.contributor.authorPalmen, Juttaen
dc.contributor.authorSpiering, Wilkoen
dc.contributor.authorde Jong, Pim Aen
dc.contributor.authorKuh, Dianaen
dc.contributor.authorHardy, Rebeccaen
dc.contributor.authorUitterlinden, Andre Gen
dc.contributor.authorIkram, M Arfanen
dc.contributor.authorFord, Ianen
dc.contributor.authorHyppönen, Elinaen
dc.contributor.authorAlmeida, Osvaldo Pen
dc.contributor.authorWareham, Nicholasen
dc.contributor.authorKhaw, Kay-Teeen
dc.contributor.authorHamsten, Andersen
dc.contributor.authorHusemoen, Lise Lotte Nen
dc.contributor.authorTjønneland, Anneen
dc.contributor.authorTolstrup, Janne Sen
dc.contributor.authorRimm, Ericen
dc.contributor.authorBeulens, Joline WJen
dc.contributor.authorVerschuren, WM Moniqueen
dc.contributor.authorOnland-Moret, N Charlotteen
dc.contributor.authorHofker, Marten Hen
dc.contributor.authorWannamethee, S Goyaen
dc.contributor.authorWhincup, Peter Hen
dc.contributor.authorMorris, Richarden
dc.contributor.authorVicente, Astrid Men
dc.contributor.authorWatkins, Hughen
dc.contributor.authorFarrall, Martinen
dc.contributor.authorJukema, J Wouteren
dc.contributor.authorMeschia, Jamesen
dc.contributor.authorCupples, L Adrienneen
dc.contributor.authorSharp, Stephenen
dc.contributor.authorFornage, Myriamen
dc.contributor.authorKooperberg, Charlesen
dc.contributor.authorLaCroix, Andrea Zen
dc.contributor.authorDai, James Yen
dc.contributor.authorLanktree, Matthew Ben
dc.contributor.authorSiscovick, David Sen
dc.contributor.authorJorgenson, Ericen
dc.contributor.authorSpring, Bonnieen
dc.contributor.authorCoresh, Josefen
dc.contributor.authorLi, Yun Ren
dc.contributor.authorBuxbaum, Sarah Gen
dc.contributor.authorSchreiner, Pamela Jen
dc.contributor.authorEllison, R Curtisen
dc.contributor.authorTsai, Michael Yen
dc.contributor.authorPatel, Sanjay Ren
dc.contributor.authorRedline, Susanen
dc.contributor.authorJohnson, Andrew Den
dc.contributor.authorHoogeveen, Ron Cen
dc.contributor.authorHakonarson, Hakonen
dc.contributor.authorRotter, Jerome Ien
dc.contributor.authorBoerwinkle, Ericen
dc.contributor.authorde Bakker, Paul IWen
dc.contributor.authorKivimaki, Mikaen
dc.contributor.authorAsselbergs, Folkert Wen
dc.contributor.authorSattar, Naveeden
dc.contributor.authorLawlor, Debbie Aen
dc.contributor.authorWhittaker, Johnen
dc.contributor.authorDavey Smith, Georgeen
dc.contributor.authorMukamal, Kennethen
dc.contributor.authorPsaty, Bruce Men
dc.contributor.authorWilson, James Gen
dc.contributor.authorLange, Leslie Aen
dc.contributor.authorHamidovic, Ajnaen
dc.contributor.authorHingorani, Aroon Den
dc.contributor.authorNordestgaard, Børge Gen
dc.contributor.authorBobak, Martinen
dc.contributor.authorLeon, David Aen
dc.contributor.authorLangenberg, Claudiaen
dc.contributor.authorPalmer, Tom Men
dc.contributor.authorReiner, Alex Pen
dc.contributor.authorKeating, Brendan Jen
dc.contributor.authorDudbridge, Franken
dc.contributor.authorCasas, Juan Pen
dc.contributor.authorInterAct Consortium,en
dc.date.accessioned2018-09-29T06:10:08Z
dc.date.available2018-09-29T06:10:08Z
dc.date.issued2014-07-10en
dc.identifier.issn1756-1833
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/282974
dc.description.abstractOBJECTIVE: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN: Mendelian randomisation meta-analysis of 56 epidemiological studies. PARTICIPANTS: 261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers. MAIN OUTCOME MEASURES: Odds ratio for coronary heart disease and stroke associated with the ADH1B variant in all individuals and by categories of alcohol consumption. RESULTS: Carriers of the A-allele of ADH1B rs1229984 consumed 17.2% fewer units of alcohol per week (95% confidence interval 15.6% to 18.9%), had a lower prevalence of binge drinking (odds ratio 0.78 (95% CI 0.73 to 0.84)), and had higher abstention (odds ratio 1.27 (1.21 to 1.34)) than non-carriers. Rs1229984 A-allele carriers had lower systolic blood pressure (-0.88 (-1.19 to -0.56) mm Hg), interleukin-6 levels (-5.2% (-7.8 to -2.4%)), waist circumference (-0.3 (-0.6 to -0.1) cm), and body mass index (-0.17 (-0.24 to -0.10) kg/m(2)). Rs1229984 A-allele carriers had lower odds of coronary heart disease (odds ratio 0.90 (0.84 to 0.96)). The protective association of the ADH1B rs1229984 A-allele variant remained the same across all categories of alcohol consumption (P=0.83 for heterogeneity). Although no association of rs1229984 was identified with the combined subtypes of stroke, carriers of the A-allele had lower odds of ischaemic stroke (odds ratio 0.83 (0.72 to 0.95)). CONCLUSIONS: Individuals with a genetic variant associated with non-drinking and lower alcohol consumption had a more favourable cardiovascular profile and a reduced risk of coronary heart disease than those without the genetic variant. This suggests that reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health.
dc.format.mediumElectronicen
dc.languageengen
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectInterAct Consortiumen
dc.subjectHumansen
dc.subjectCoronary Diseaseen
dc.subjectAlcohol Dehydrogenaseen
dc.subjectGenetic Markersen
dc.subjectModels, Statisticalen
dc.subjectAlcohol Drinkingen
dc.subjectGenotypeen
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectStrokeen
dc.subjectMendelian Randomization Analysisen
dc.subjectBiomarkersen
dc.titleAssociation between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.en
dc.typeArticle
prism.publicationDate2014en
prism.publicationNameBMJ (Clinical research ed.)en
prism.startingPageg4164
prism.volume349en
dc.identifier.doi10.17863/CAM.30336
dcterms.dateAccepted2014-05-21en
rioxxterms.versionofrecord10.1136/bmj.g4164en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-07-10en
dc.contributor.orcidZuccolo, Luisa [0000-0002-7049-3037]
dc.contributor.orcidSilverwood, Richard J [0000-0002-2744-1194]
dc.contributor.orcidPrieto-Merino, David [0000-0001-5001-0061]
dc.contributor.orcidDehghan, Abbas [0000-0001-6403-016X]
dc.contributor.orcidWong, Andrew [0000-0003-2079-4779]
dc.contributor.orcidCavadino, Alana [0000-0002-5709-367X]
dc.contributor.orcidPadmanabhan, Sandosh [0000-0003-3869-5808]
dc.contributor.orcidSundstrom, Johan [0000-0003-2247-8454]
dc.contributor.orcidPikhart, Hynek [0000-0001-5277-4049]
dc.contributor.orcidSwerdlow, Daniel I [0000-0002-7946-3459]
dc.contributor.orcidEngmann, Jorgen [0000-0001-7015-7773]
dc.contributor.orcidFolkersen, Lasse [0000-0003-0708-9530]
dc.contributor.orcidEriksson, Per [0000-0002-5635-2692]
dc.contributor.orcidRicceri, Fulvio [0000-0001-8749-9737]
dc.contributor.orcidSacerdote, Carlotta [0000-0002-8008-5096]
dc.contributor.orcidRayaprolu, Sruti [0000-0002-5212-3745]
dc.contributor.orcidRoss, Owen A [0000-0003-4813-756X]
dc.contributor.orcidMarques-Vidal, Pedro [0000-0002-4548-8500]
dc.contributor.orcidMarmot, Michael G [0000-0002-2431-6419]
dc.contributor.orcidHumphries, Steve E [0000-0002-8221-6547]
dc.contributor.orcidTalmud, Philippa J [0000-0002-5560-1933]
dc.contributor.orcidVerweij, Niek [0000-0002-4303-7685]
dc.contributor.orcidLinneberg, Allan [0000-0002-0994-0184]
dc.contributor.orcidSkaaby, Tea [0000-0003-0031-5726]
dc.contributor.orcidDominiczak, Anna F [0000-0003-4913-3608]
dc.contributor.orcidKumari, Meena [0000-0001-9716-1035]
dc.contributor.orcidGaunt, Tom R [0000-0003-0924-3247]
dc.contributor.orcidPeasey, Anne [0000-0001-7434-2079]
dc.contributor.orcidMalyutina, Sofia [0000-0001-6539-0466]
dc.contributor.orcidHankey, Graeme J [0000-0002-6044-7328]
dc.contributor.orcidFranco, Oscar H [0000-0002-4606-4929]
dc.contributor.orcidHardy, Rebecca [0000-0001-9949-0799]
dc.contributor.orcidHyppönen, Elina [0000-0003-3670-9399]
dc.contributor.orcidAlmeida, Osvaldo P [0000-0002-8689-6199]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidKhaw, Kay-Tee [0000-0002-8802-2903]
dc.contributor.orcidTjønneland, Anne [0000-0003-4385-2097]
dc.contributor.orcidTolstrup, Janne S [0000-0002-9796-3967]
dc.contributor.orcidWhincup, Peter H [0000-0002-5589-4107]
dc.contributor.orcidMorris, Richard [0000-0001-7240-4563]
dc.contributor.orcidVicente, Astrid M [0000-0001-7134-8037]
dc.contributor.orcidWatkins, Hugh [0000-0002-5287-9016]
dc.contributor.orcidFarrall, Martin [0000-0003-4564-2165]
dc.contributor.orcidCupples, L Adrienne [0000-0003-0273-7965]
dc.contributor.orcidSharp, Stephen [0000-0003-2375-1440]
dc.contributor.orcidDai, James Y [0000-0002-7720-8032]
dc.contributor.orcidLanktree, Matthew B [0000-0002-5750-6286]
dc.contributor.orcidSpring, Bonnie [0000-0003-0692-9868]
dc.contributor.orcidBuxbaum, Sarah G [0000-0002-4886-3564]
dc.contributor.orcidTsai, Michael Y [0000-0001-7553-3408]
dc.contributor.orcidPatel, Sanjay R [0000-0002-9142-5172]
dc.contributor.orcidHoogeveen, Ron C [0000-0003-2399-4653]
dc.contributor.orcidKivimaki, Mika [0000-0002-4699-5627]
dc.contributor.orcidAsselbergs, Folkert W [0000-0002-1692-8669]
dc.contributor.orcidLawlor, Debbie A [0000-0002-6793-2262]
dc.contributor.orcidWhittaker, John [0000-0002-3529-2379]
dc.contributor.orcidDavey Smith, George [0000-0002-1407-8314]
dc.contributor.orcidBobak, Martin [0000-0002-2633-6851]
dc.contributor.orcidLeon, David A [0000-0001-9747-1762]
dc.contributor.orcidLangenberg, Claudia [0000-0002-5017-7344]
dc.contributor.orcidPalmer, Tom M [0000-0003-4655-4511]
dc.identifier.eissn1756-1833
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G1000143)
pubs.funder-project-idMRC (MC_UU_12015/1)
pubs.funder-project-idNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (U01DK062418)
pubs.funder-project-idMedical Research Council (G0701863)
pubs.funder-project-idESRC (ES/I025561/2)
pubs.funder-project-idMRC (G0401527)
pubs.funder-project-idMedical Research Council (MC_U106179471)


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International