Detecting RNA G-Quadruplexes (rG4s) in the Transcriptome.
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Publication Date
2018-07-02Journal Title
Cold Spring Harbor Perspectives in Biology
ISSN
1943-0264
Publisher
Cold Spring Harbor Laboratory Press
Volume
10
Issue
7
Number
a032284
Language
eng
Type
Article
Metadata
Show full item recordCitation
Kwok, C. K., Marsico, G., & Balasubramanian, S. (2018). Detecting RNA G-Quadruplexes (rG4s) in the Transcriptome.. Cold Spring Harbor Perspectives in Biology, 10 (7. a032284) https://doi.org/10.1101/cshperspect.a032284
Abstract
SUMMARY
RNA G-quadruplex (rG4) secondary structures are proposed to play key roles in fundamental biological processes that include the modulation of transcriptional, co-transcriptional, and posttranscriptional events. Recent methodological developments that include predictive algorithms and structure-based sequencing have enabled the detection and mapping of rG4 structures on a transcriptome-wide scale at high sensitivity and resolution. The data generated by these studies provide valuable insights into the potentially diverse roles of rG4s in biology and open up a number of mechanistic hypotheses. Herein we highlight these methodologies and discuss the associated findings in relation to rG4-related biological mechanisms.
Sponsorship
The Balasubramanian laboratory is supported by European Research Council Advanced Grant No. 339778, a Wellcome Trust Senior Investigator Award, and core funding from Cancer Research UK. The Kwok laboratory is supported by City University of Hong Kong Project No. 9610363, 7200520, Croucher Foundation Project No. 9500030, and Hong Kong RGC Project No. CityU 21302317, N_CityU110/17.
Funder references
European Research Council (339778)
Identifiers
External DOI: https://doi.org/10.1101/cshperspect.a032284
This record's URL: https://www.repository.cam.ac.uk/handle/1810/283013
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