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dc.contributor.authorKwok, Chun Kit
dc.contributor.authorMarsico, Giovanni
dc.contributor.authorBalasubramanian, Shankar
dc.date.accessioned2018-10-03T04:43:09Z
dc.date.available2018-10-03T04:43:09Z
dc.date.issued2018-07-02
dc.identifier.issn1943-0264
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283013
dc.description.abstractSUMMARY RNA G-quadruplex (rG4) secondary structures are proposed to play key roles in fundamental biological processes that include the modulation of transcriptional, co-transcriptional, and posttranscriptional events. Recent methodological developments that include predictive algorithms and structure-based sequencing have enabled the detection and mapping of rG4 structures on a transcriptome-wide scale at high sensitivity and resolution. The data generated by these studies provide valuable insights into the potentially diverse roles of rG4s in biology and open up a number of mechanistic hypotheses. Herein we highlight these methodologies and discuss the associated findings in relation to rG4-related biological mechanisms.
dc.description.sponsorshipThe Balasubramanian laboratory is supported by European Research Council Advanced Grant No. 339778, a Wellcome Trust Senior Investigator Award, and core funding from Cancer Research UK. The Kwok laboratory is supported by City University of Hong Kong Project No. 9610363, 7200520, Croucher Foundation Project No. 9500030, and Hong Kong RGC Project No. CityU 21302317, N_CityU110/17.
dc.languageeng
dc.publisherCold Spring Harbor Laboratory Press
dc.titleDetecting RNA G-Quadruplexes (rG4s) in the Transcriptome.
dc.typeArticle
prism.issueIdentifier7
prism.numbera032284
prism.publicationDate2018
prism.publicationNameCold Spring Harbor Perspectives in Biology
prism.volume10
dc.identifier.doi10.17863/CAM.30377
dcterms.dateAccepted2018-06-29
rioxxterms.versionofrecord10.1101/cshperspect.a032284
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-07-02
dc.contributor.orcidBalasubramanian, Shankar [0000-0002-0281-5815]
dc.identifier.eissn1943-0264
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Research Council (339778)
cam.issuedOnline2018-07-02
rioxxterms.freetoread.startdate2019-07-02


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