The MesoVATS trial: is there a future for video-assisted thoracoscopic surgery partial pleurectomy?
Rintoul, Robert C
Future Medicine Ltd
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Rintoul, R. C. (2015). The MesoVATS trial: is there a future for video-assisted thoracoscopic surgery partial pleurectomy?. Future Oncol, 11 (24 Suppl), 15-17. https://doi.org/10.2217/fon.15.274
Malignant pleural mesothelioma, a uniformly fatal cancer caused by prior asbestos exposure, places a major burden on society. The MesoVATS trial was a multicenter randomized controlled trial that examined the role of video-assisted thoracoscopic partial pleurectomy (VAT-PP) versus talc pleurodesis in patients with malignant pleural mesothelioma. Overall there was no difference in survival between VAT-PP and talc pleurodesis. VAT-PP resulted in more complications, longer hospital stay and was more expensive. However, there was some evidence that VAT-PP improved EQ5D measured quality of life after 6 months particularly in the European Organisation for Research and Treatment of Cancer low-risk subgroup. At present the future role of VAT-PP is uncertain and may merit further investigation but this should be within the context of clinical trials. VAT-PP may also have a role to play in the specific situation of trapped lung.
Humans, Mesothelioma, Lung Neoplasms, Pleural Neoplasms, Thoracic Surgery, Video-Assisted, Quality of Life, Aged, Female, Male, Clinical Trials as Topic, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Mesothelioma, Malignant
External DOI: https://doi.org/10.2217/fon.15.274
This record's URL: https://www.repository.cam.ac.uk/handle/1810/283024