Show simple item record

dc.contributor.authorHernandez-Fuentes, Maria P
dc.contributor.authorFranklin, Christopher
dc.contributor.authorRebollo-Mesa, Irene
dc.contributor.authorMollon, Jennifer
dc.contributor.authorDelaney, Florence
dc.contributor.authorPerucha, Esperanza
dc.contributor.authorStapleton, Caragh
dc.contributor.authorBorrows, Richard
dc.contributor.authorByrne, Catherine
dc.contributor.authorCavalleri, Gianpiero
dc.contributor.authorClarke, Brendan
dc.contributor.authorClatworthy, Menna
dc.contributor.authorFeehally, John
dc.contributor.authorFuggle, Susan
dc.contributor.authorGagliano, Sarah A
dc.contributor.authorGriffin, Sian
dc.contributor.authorHammad, Abdul
dc.contributor.authorHiggins, Robert
dc.contributor.authorJardine, Alan
dc.contributor.authorKeogan, Mary
dc.contributor.authorLeach, Timothy
dc.contributor.authorMacPhee, Iain
dc.contributor.authorMark, Patrick B
dc.contributor.authorMarsh, James
dc.contributor.authorMaxwell, Peter
dc.contributor.authorMcKane, William
dc.contributor.authorMcLean, Adam
dc.contributor.authorNewstead, Charles
dc.contributor.authorAugustine, Titus
dc.contributor.authorPhelan, Paul
dc.contributor.authorPowis, Steve
dc.contributor.authorRowe, Peter
dc.contributor.authorSheerin, Neil
dc.contributor.authorSolomon, Ellen
dc.contributor.authorStephens, Henry
dc.contributor.authorThuraisingham, Raj
dc.contributor.authorTrembath, Richard
dc.contributor.authorTopham, Peter
dc.contributor.authorVaughan, Robert
dc.contributor.authorSacks, Steven H
dc.contributor.authorConlon, Peter
dc.contributor.authorOpelz, Gerhard
dc.contributor.authorSoranzo, Nicole
dc.contributor.authorWeale, Michael E
dc.contributor.authorLord, Graham M
dc.contributor.authorUnited Kingdom and Ireland Renal Transplant Consortium (UKIRTC) and the Wellcome Trust Case Control Consortium (WTCCC)-3
dc.date.accessioned2018-10-03T04:44:21Z
dc.date.available2018-10-03T04:44:21Z
dc.date.issued2018-06
dc.identifier.issn1600-6135
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283055
dc.description.abstractImprovements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate of long-term failure. Mismatches between donor and recipient HLA play an important role in the acute and chronic allogeneic immune response against the graft. Perfect matching at clinically relevant HLA loci does not obviate the need for immunosuppression, suggesting that additional genetic variation plays a critical role in both short- and long-term graft outcomes. By combining patient data and samples from supranational cohorts across the United Kingdom and European Union, we performed the first large-scale genome-wide association study analyzing both donor and recipient DNA in 2094 complete renal transplant-pairs with replication in 5866 complete pairs. We studied deceased-donor grafts allocated on the basis of preferential HLA matching, which provided some control for HLA genetic effects. No strong donor or recipient genetic effects contributing to long- or short-term allograft survival were found outside the HLA region. We discuss the implications for future research and clinical application.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherWiley
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectUnited Kingdom and Ireland Renal Transplant Consortium (UKIRTC) and the Wellcome Trust Case Control Consortium (WTCCC)-3
dc.subjectHumans
dc.subjectHistocompatibility Testing
dc.subjectKidney Transplantation
dc.subjectTransplantation, Homologous
dc.subjectGraft Survival
dc.subjectDNA Replication
dc.subjectGenotype
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectTissue Donors
dc.subjectFemale
dc.subjectMale
dc.subjectGenome-Wide Association Study
dc.subjectTransplant Recipients
dc.titleLong- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study.
dc.typeArticle
prism.endingPage1379
prism.issueIdentifier6
prism.publicationDate2018
prism.publicationNameAm J Transplant
prism.startingPage1370
prism.volume18
dc.identifier.doi10.17863/CAM.30418
dcterms.dateAccepted2017-11-13
rioxxterms.versionofrecord10.1111/ajt.14594
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-06
dc.contributor.orcidHernandez-Fuentes, Maria P [0000-0002-7558-9441]
dc.contributor.orcidFranklin, Christopher [0000-0003-3893-0759]
dc.contributor.orcidPerucha, Esperanza [0000-0002-7802-0875]
dc.contributor.orcidStapleton, Caragh [0000-0002-5354-7822]
dc.contributor.orcidByrne, Catherine [0000-0002-0741-2521]
dc.contributor.orcidCavalleri, Gianpiero [0000-0002-9802-0506]
dc.contributor.orcidClarke, Brendan [0000-0001-9945-6646]
dc.contributor.orcidClatworthy, Menna [0000-0002-3340-9828]
dc.contributor.orcidGagliano, Sarah A [0000-0003-1306-1868]
dc.contributor.orcidGriffin, Sian [0000-0001-5860-9036]
dc.contributor.orcidHammad, Abdul [0000-0002-4952-0096]
dc.contributor.orcidHiggins, Robert [0000-0003-1960-0359]
dc.contributor.orcidJardine, Alan [0000-0001-5815-9370]
dc.contributor.orcidKeogan, Mary [0000-0002-2596-0660]
dc.contributor.orcidMacPhee, Iain [0000-0003-2322-7622]
dc.contributor.orcidMark, Patrick B [0000-0003-3387-2123]
dc.contributor.orcidMaxwell, Peter [0000-0002-6110-7253]
dc.contributor.orcidAugustine, Titus [0000-0002-7391-1839]
dc.contributor.orcidPhelan, Paul [0000-0003-2549-5049]
dc.contributor.orcidPowis, Steve [0000-0003-2534-6131]
dc.contributor.orcidSheerin, Neil [0000-0002-3743-2371]
dc.contributor.orcidStephens, Henry [0000-0001-8657-4766]
dc.contributor.orcidTrembath, Richard [0000-0003-0550-3400]
dc.contributor.orcidConlon, Peter [0000-0001-6772-9531]
dc.contributor.orcidSoranzo, Nicole [0000-0003-1095-3852]
dc.contributor.orcidWeale, Michael E [0000-0003-4593-1186]
dc.contributor.orcidLord, Graham M [0000-0003-2069-4743]
dc.identifier.eissn1600-6143
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (081020/Z/06/Z)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NIHR BTRU-2014-10027)
pubs.funder-project-idEuropean Commission (257082)
pubs.funder-project-idWellcome Trust (091310/Z/10/Z)
cam.issuedOnline2018-02


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International