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dc.contributor.authorCreeth, HDJ
dc.contributor.authorMcNamara, GI
dc.contributor.authorTunster, SJ
dc.contributor.authorBoque-Sastre, R
dc.contributor.authorAllen, B
dc.contributor.authorSumption, L
dc.contributor.authorEddy, JB
dc.contributor.authorIsles, AR
dc.contributor.authorJohn, RM
dc.date.accessioned2018-10-03T04:44:41Z
dc.date.available2018-10-03T04:44:41Z
dc.date.issued2018-07
dc.identifier.issn1544-9173
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283066
dc.description.abstractIn mammals, mothers are the primary caregiver, programmed, in part, by hormones produced during pregnancy. High-quality maternal care is essential for the survival and lifelong health of offspring. We previously showed that the paternally silenced imprinted gene pleckstrin homology-like domain family A member 2 (Phlda2) functions to negatively regulate a single lineage in the mouse placenta called the spongiotrophoblast, a major source of hormones in pregnancy. Consequently, the offspring's Phlda2 gene dosage may influence the quality of care provided by the mother. Here, we show that wild-type (WT) female mice exposed to offspring with three different doses of the maternally expressed Phlda2 gene-two active alleles, one active allele (the extant state), and loss of function-show changes in the maternal hypothalamus and hippocampus during pregnancy, regions important for maternal-care behaviour. After birth, WT dams exposed in utero to offspring with the highest Phlda2 dose exhibit decreased nursing and grooming of pups and increased focus on nest building. Conversely, 'paternalised' dams, exposed to the lowest Phlda2 dose, showed increased nurturing of their pups, increased self-directed behaviour, and a decreased focus on nest building, behaviour that was robustly maintained in the absence of genetically modified pups. This work raises the intriguing possibility that imprinting of Phlda2 contributed to increased maternal care during the evolution of mammals.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHippocampus
dc.subjectHypothalamus
dc.subjectAnimals
dc.subjectMice, Knockout
dc.subjectMammals
dc.subjectNuclear Proteins
dc.subjectMaternal Behavior
dc.subjectGene Expression Regulation, Developmental
dc.subjectGenomic Imprinting
dc.subjectFemale
dc.subjectMale
dc.titleMaternal care boosted by paternal imprinting in mammals.
dc.typeArticle
prism.issueIdentifier7
prism.publicationDate2018
prism.publicationNamePLoS Biol
prism.startingPagee2006599
prism.volume16
dc.identifier.doi10.17863/CAM.30428
dcterms.dateAccepted2018-06-26
rioxxterms.versionofrecord10.1371/journal.pbio.2006599
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-07-31
dc.contributor.orcidJohn, RM [0000-0002-3827-7617]
dc.identifier.eissn1545-7885
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-07-31


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International