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dc.contributor.authorKnolle, Franziska
dc.contributor.authorErmakova, Anna O
dc.contributor.authorJusticia, Azucena
dc.contributor.authorFletcher, Paul C
dc.contributor.authorBunzeck, Nico
dc.contributor.authorDüzel, Emrah
dc.contributor.authorMurray, Graham K
dc.date.accessioned2018-10-03T04:45:11Z
dc.date.available2018-10-03T04:45:11Z
dc.date.issued2018-09-21
dc.identifier.issn2158-3188
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283084
dc.description.abstractAbnormal salience processing has been suggested to contribute to the formation of positive psychotic symptoms in schizophrenia and related conditions. Previous research utilising reward learning or anticipation paradigms has demonstrated cortical and subcortical abnormalities in people with psychosis, specifically in the prefrontal cortex, the dopaminergic midbrain and the striatum. In these paradigms, reward prediction errors attribute motivational salience to stimuli. However, little is known about possible abnormalities across different forms of salience processing in psychosis patients, and whether any such abnormalities involve the dopaminergic midbrain. The aim of our study was, therefore, to investigate possible alterations in psychosis in neural activity in response to various forms of salience: novelty, negative emotion, targetness (task-driven salience) and rareness/deviance. We studied 14 antipsychotic naïve participants with first episode psychosis, and 37 healthy volunteers. During fMRI scanning, participants performed a visual oddball task containing these four forms of salience. Psychosis patients showed abnormally reduced signalling in the substantia nigra/ventral tegmental area (SN/VTA) for novelty, negative emotional salience and targetness; reduced striatal and occipital (lingual gyrus) signalling to novelty and negative emotional salience, reduced signalling in the amygdala, anterior cingulate cortex and parahippocamal gyrus to negative emotional salience, and reduced cerebellar signalling to novelty and negative emotional salience. Our results indicate alterations of several forms of salience processing in patients with psychosis in the midbrain SN/VTA, with additional subcortical and cortical regions also showing alterations in salience signalling, the exact pattern of alterations depending on the form of salience in question.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectSubstantia Nigra
dc.subjectVentral Tegmental Area
dc.subjectAmygdala
dc.subjectGyrus Cinguli
dc.subjectHumans
dc.subjectAntipsychotic Agents
dc.subjectMagnetic Resonance Imaging
dc.subjectBrain Mapping
dc.subjectCase-Control Studies
dc.subjectPhotic Stimulation
dc.subjectMotivation
dc.subjectReward
dc.subjectSchizophrenia
dc.subjectAdolescent
dc.subjectAdult
dc.subjectFemale
dc.subjectMale
dc.subjectYoung Adult
dc.subjectApplied Behavior Analysis
dc.titleBrain responses to different types of salience in antipsychotic naïve first episode psychosis: An fMRI study.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2018
prism.publicationNameTransl Psychiatry
prism.startingPage196
prism.volume8
dc.identifier.doi10.17863/CAM.30446
dcterms.dateAccepted2018-07-24
rioxxterms.versionofrecord10.1038/s41398-018-0250-3
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-09-21
dc.contributor.orcidKnolle, Franziska [0000-0002-9542-613X]
dc.contributor.orcidErmakova, Anna O [0000-0002-1869-0084]
dc.contributor.orcidBunzeck, Nico [0000-0001-8834-450X]
dc.identifier.eissn2158-3188
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCambridgeshire and Peterborough NHS Foundation Trust (CPFT) (unknown)
pubs.funder-project-idMedical Research Council (G0701911)
pubs.funder-project-idMedical Research Council (G1000183)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)
pubs.funder-project-idWellcome Trust (095692/Z/11/Z)
pubs.funder-project-idMedical Research Council (G0001354)
cam.issuedOnline2018-09-21


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International