A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in a spider.
View / Open Files
Authors
Schoenauer, Anna
Leite, Daniel J
Publication Date
2018-08-21Journal Title
Elife
ISSN
2050-084X
Publisher
eLife Sciences Publications, Ltd
Volume
7
Language
eng
Type
Article
Physical Medium
Electronic
Metadata
Show full item recordCitation
Paese, C. L. B., Schoenauer, A., Leite, D. J., Russell, S., & McGregor, A. P. (2018). A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in a spider.. Elife, 7 https://doi.org/10.7554/eLife.37567
Abstract
Sox genes encode a set of highly conserved transcription factors that regulate many developmental processes. In insects, the SoxB gene Dichaete is the only Sox gene known to be involved in segmentation. To determine if similar mechanisms are used in other arthropods, we investigated the role of Sox genes during segmentation in the spider Parasteatoda tepidariorum. While Dichaete does not appear to be involved in spider segmentation, we found that the closely related Sox21b-1 gene acts as a gap gene during formation of anterior segments and is also part of the segmentation clock for development of the segment addition zone and sequential addition of opisthosomal segments. Thus, we have found that two different mechanisms of segmentation in a non-mandibulate arthropod are regulated by a SoxB gene. Our work provides new insights into the function of an important and conserved gene family, and the evolution of the regulation of segmentation in arthropods.
Keywords
Animals, Spiders, Gene Expression Regulation, Developmental, Body Patterning, SOXB2 Transcription Factors, Biological Evolution
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/N007069/1)
Biotechnology and Biological Sciences Research Council (BB/L002817/1)
Identifiers
External DOI: https://doi.org/10.7554/eLife.37567
This record's URL: https://www.repository.cam.ac.uk/handle/1810/283095
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.