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dc.contributor.authorJanuszewicz, Wladyslaw
dc.contributor.authorTan, Wei Keith
dc.contributor.authorLehovsky, Katie
dc.contributor.authorDebiram-Beecham, Irene
dc.contributor.authorNuckcheddy, Tara
dc.contributor.authorMoist, Susan
dc.contributor.authorKadri, Sudarshan
dc.contributor.authordi Pietro, Massimiliano
dc.contributor.authorBoussioutas, Alex
dc.contributor.authorShaheen, Nicholas J
dc.contributor.authorKatzka, David A
dc.contributor.authorDellon, Evan S
dc.contributor.authorFitzgerald, Rebecca C
dc.contributor.authorBEST1 and BEST2 study investigators
dc.date.accessioned2018-10-03T04:45:47Z
dc.date.available2018-10-03T04:45:47Z
dc.date.issued2019-03
dc.identifier.issn1542-3565
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283106
dc.description.abstractBACKGROUND & AIMS: Diagnosis and surveillance of Barrett's esophagus (BE) and eosinophilic esophagitis (EoE) have become emerging public health issues. Cytosponge is a novel, minimally invasive esophageal cell collection device. We aimed to assess the data on safety and acceptability of this device. METHODS: We performed a patient-level review of 5 prospective trials assessing Cytosponge performance in patients with reflux disease, BE and EoE in primary and secondary care. Acceptability of Cytosponge and subsequent endoscopy were recorded with visual analogue scale (VAS), wherein 0 and 10 denoted lowest and highest acceptability. Median VAS scores were compared using a Mann-Whitney test. The number of attempts, failures in swallowing the device and occurrence of adverse events were analyzed. Risk factors for failure in swallowing were analyzed using a multivariate regression model. RESULTS: In total, 2672 Cytosponge procedures were performed, in 2418 individuals from 2008 through 2017. There were 2 adverse events related to the device: a minor pharyngeal bleed and a case of detachment (<1:2000). The median acceptability score for the Cytosponge was 6.0 (interquartile range [IQR], 5.0-8.0), which was higher than the score for endoscopy without sedation (median 5.0; IQR, 3.0-7.0; P < .001) and lower than the score for endoscopy with sedation (median 8.0; IQR, 5.0-9.0; P < .001). Nearly all patients (91.1%) successfully swallowed the Cytosponge, most on the first attempt (90.1%). Failure to swallow the device was more likely to occur in secondary care (odds ratio, 5.13; 95% CI, 1.48-17.79; P < .01). CONCLUSIONS: The Cytosponge test is a safe procedure with good acceptability ratings in a variety of health care settings.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherElsevier BV
dc.subjectBEST1 and BEST2 study investigators
dc.subjectHumans
dc.subjectBarrett Esophagus
dc.subjectMass Screening
dc.subjectSpecimen Handling
dc.subjectCytological Techniques
dc.subjectRisk Factors
dc.subjectRetrospective Studies
dc.subjectProspective Studies
dc.subjectEquipment and Supplies
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectPatient Acceptance of Health Care
dc.subjectFemale
dc.subjectMale
dc.subjectEosinophilic Esophagitis
dc.subjectPatient Safety
dc.titleSafety and Acceptability of Esophageal Cytosponge Cell Collection Device in a Pooled Analysis of Data From Individual Patients.
dc.typeArticle
prism.endingPage656.e1
prism.issueIdentifier4
prism.publicationDate2019
prism.publicationNameClin Gastroenterol Hepatol
prism.startingPage647
prism.volume17
dc.identifier.doi10.17863/CAM.30467
dcterms.dateAccepted2018-07-28
rioxxterms.versionofrecord10.1016/j.cgh.2018.07.043
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-03
dc.contributor.orcidDi Pietro, Massimiliano [0000-0003-4866-7026]
dc.contributor.orcidFitzgerald, Rebecca [0000-0002-3434-3568]
dc.identifier.eissn1542-7714
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idMRC (unknown)
pubs.funder-project-idMedical Research Council (MC_UU_12022/2)
pubs.funder-project-idNational Institute of Diabetes and Digestive and Kidney Diseases (K24DK100548)
pubs.funder-project-idCancer Research UK (C14478/A12088)
cam.issuedOnline2018-08-09
rioxxterms.freetoread.startdate2019-08-09


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