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dc.contributor.authorLee, James J
dc.contributor.authorWedow, Robbee
dc.contributor.authorOkbay, Aysu
dc.contributor.authorKong, Edward
dc.contributor.authorMaghzian, Omeed
dc.contributor.authorZacher, Meghan
dc.contributor.authorNguyen-Viet, Tuan Anh
dc.contributor.authorBowers, Peter
dc.contributor.authorSidorenko, Julia
dc.contributor.authorKarlsson Linnér, Richard
dc.contributor.authorFontana, Mark Alan
dc.contributor.authorKundu, Tushar
dc.contributor.authorLee, Chanwook
dc.contributor.authorLi, Hui
dc.contributor.authorLi, Ruoxi
dc.contributor.authorRoyer, Rebecca
dc.contributor.authorTimshel, Pascal N
dc.contributor.authorWalters, Raymond K
dc.contributor.authorWilloughby, Emily A
dc.contributor.authorYengo, Loïc
dc.contributor.author23andMe Research Team
dc.contributor.authorCOGENT (Cognitive Genomics Consortium)
dc.contributor.authorSocial Science Genetic Association Consortium
dc.contributor.authorAlver, Maris
dc.contributor.authorBao, Yanchun
dc.contributor.authorClark, David W
dc.contributor.authorDay, Felix
dc.contributor.authorFurlotte, Nicholas A
dc.contributor.authorJoshi, Peter K
dc.contributor.authorKemper, Kathryn E
dc.contributor.authorKleinman, Aaron
dc.contributor.authorLangenberg, Claudia
dc.contributor.authorMägi, Reedik
dc.contributor.authorTrampush, Joey W
dc.contributor.authorVerma, Shefali Setia
dc.contributor.authorWu, Yang
dc.contributor.authorLam, Max
dc.contributor.authorZhao, Jing Hua
dc.contributor.authorZheng, Zhili
dc.contributor.authorBoardman, Jason D
dc.contributor.authorCampbell, Harry
dc.contributor.authorFreese, Jeremy
dc.contributor.authorHarris, Kathleen Mullan
dc.contributor.authorHayward, Caroline
dc.contributor.authorHerd, Pamela
dc.contributor.authorKumari, Meena
dc.contributor.authorLencz, Todd
dc.contributor.authorLuan, Jian'an
dc.contributor.authorMalhotra, Anil K
dc.contributor.authorMetspalu, Andres
dc.contributor.authorMilani, Lili
dc.contributor.authorOng, Kenneth
dc.contributor.authorPerry, John
dc.contributor.authorPorteous, David J
dc.contributor.authorRitchie, Marylyn D
dc.contributor.authorSmart, Melissa C
dc.contributor.authorSmith, Blair H
dc.contributor.authorTung, Joyce Y
dc.contributor.authorWareham, Nicholas
dc.contributor.authorWilson, James F
dc.contributor.authorBeauchamp, Jonathan P
dc.contributor.authorConley, Dalton C
dc.contributor.authorEsko, Tõnu
dc.contributor.authorLehrer, Steven F
dc.contributor.authorMagnusson, Patrik KE
dc.contributor.authorOskarsson, Sven
dc.contributor.authorPers, Tune H
dc.contributor.authorRobinson, Matthew R
dc.contributor.authorThom, Kevin
dc.contributor.authorWatson, Chelsea
dc.contributor.authorChabris, Christopher F
dc.contributor.authorMeyer, Michelle N
dc.contributor.authorLaibson, David I
dc.contributor.authorYang, Jian
dc.contributor.authorJohannesson, Magnus
dc.contributor.authorKoellinger, Philipp D
dc.contributor.authorTurley, Patrick
dc.contributor.authorVisscher, Peter M
dc.contributor.authorBenjamin, Daniel J
dc.contributor.authorCesarini, David
dc.date.accessioned2018-10-03T08:58:51Z
dc.date.available2018-10-03T08:58:51Z
dc.date.issued2018-08
dc.identifier.issn1061-4036
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283132
dc.description.abstractHere we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.
dc.description.sponsorshipMedical Research Council (MC_UU_12015/1), Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135), MRC (MC_PC_13048), Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
dc.languageeng
dc.language.isoen
dc.publisherSpringer Nature
dc.titleGene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
dc.typeArticle
prism.endingPage1121
prism.issueIdentifier8
prism.publicationDate2018
prism.publicationNameNature Genetics
prism.startingPage1112
prism.volume50
dc.identifier.doi10.17863/CAM.30493
dcterms.dateAccepted2018-04-30
rioxxterms.versionofrecord10.1038/s41588-018-0147-3
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-08
dc.contributor.orcidDay, Felix [0000-0003-3789-7651]
dc.contributor.orcidLangenberg, Claudia [0000-0002-5017-7344]
dc.contributor.orcidZhao, Jing Hua [0000-0003-4930-3582]
dc.contributor.orcidLuan, Jian'an [0000-0003-3137-6337]
dc.contributor.orcidOng, Kenneth [0000-0003-4689-7530]
dc.contributor.orcidPerry, John [0000-0001-6483-3771]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.identifier.eissn1546-1718
dc.publisher.urlhttps://www.nature.com/articles/s41588-018-0147-3
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_12015/1)
pubs.funder-project-idMRC (MC_PC_13048)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
pubs.funder-project-idMedical Research Council (MC_UU_12015/2)
cam.issuedOnline2018-07-23
dc.identifier.urlhttps://www.nature.com/articles/s41588-018-0147-3
rioxxterms.freetoread.startdate2019-01-23


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