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dc.contributor.authorHosgood, Sarah
dc.contributor.authorThompson, E
dc.contributor.authorMoore, T
dc.contributor.authorWilson, CH
dc.contributor.authorNicholson, Michael
dc.date.accessioned2018-10-03T15:27:28Z
dc.date.available2018-10-03T15:27:28Z
dc.date.issued2018-03
dc.identifier.issn0007-1323
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283153
dc.description.abstractBACKGROUND: A significant proportion of donation after circulatory death (DCD) kidneys are declined for transplantation because of concerns over their quality. Ex vivo normothermic machine perfusion (NMP) provides a unique opportunity to assess the quality of a kidney and determine its suitability for transplantation. METHODS: In phase 1 of this study, declined human DCD kidneys underwent NMP assessment for 60 min. Kidneys were graded 1-5 using a quality assessment score (QAS) based on macroscopic perfusion, renal blood flow and urine output during NMP. In phase 2 of the study, declined DCD kidneys were assessed by NMP with an intention to transplant them. RESULTS: In phase 1, 18 of 42 DCD kidneys were declined owing to poor in situ perfusion. After NMP, 28 kidneys had a QAS of 1-3, and were considered suitable for transplantation. In phase 2, ten of 55 declined DCD kidneys underwent assessment by NMP. Eight kidneys had been declined because of poor in situ flushing in the donor and five of these were transplanted successfully. Four of the five kidneys had initial graft function. CONCLUSION: NMP technology can be used to increase the number of DCD kidney transplants by assessing their quality before transplantation.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectKidney
dc.subjectHumans
dc.subjectDeath
dc.subjectOrgan Preservation
dc.subjectKidney Transplantation
dc.subjectDonor Selection
dc.subjectPerfusion
dc.subjectTemperature
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectOutcome Assessment, Health Care
dc.titleNormothermic machine perfusion for the assessment and transplantation of declined human kidneys from donation after circulatory death donors.
dc.typeArticle
prism.endingPage394
prism.issueIdentifier4
prism.publicationDate2018
prism.publicationNameBr J Surg
prism.startingPage388
prism.volume105
dc.identifier.doi10.17863/CAM.30516
dcterms.dateAccepted2017-09-21
rioxxterms.versionofrecord10.1002/bjs.10733
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-03
dc.contributor.orcidHosgood, Sarah [0000-0002-8039-143X]
dc.contributor.orcidNicholson, Michael [0000-0001-7620-0664]
dc.identifier.eissn1365-2168
rioxxterms.typeJournal Article/Review
cam.issuedOnline2017-12-06


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International