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dc.contributor.authorSun, Qianen
dc.contributor.authorZhao, Ziyanen
dc.contributor.authorHall, Lisaen
dc.contributor.authorRouth, Alexen
dc.date.accessioned2018-10-03T15:27:55Z
dc.date.available2018-10-03T15:27:55Z
dc.date.issued2018-01en
dc.identifier.issn2296-2646
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283166
dc.description.abstractColloidosomes are polymer shell microcapsules. They are stable and easy to prepare and have been used to encapsulate drugs for release at specific areas in the body. Traditional polymer shell capsules cannot totally seal drugs, since they are porous and small molecules diffuse through the polymer shell. In this paper, we report a method for encapsulating an antibiotic kanamycin using gold or silver coated colloidosomes. The colloidosomes are impermeable and can be triggered using ultrasound. To investigate the application of the capsules in a biological system, Escherichia Coli (E.coli) was chosen as a model organism. After triggering, the released antibiotic, as well as the metal shell fragments, kill E.coli. Both the silver and gold shells colloidosomes are toxic to this bacterial system and the gold coated colloidosomes can load a higher concentration of kanamycin.
dc.description.sponsorshipChina Scholarship Council
dc.format.mediumElectronic-eCollectionen
dc.languageengen
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleMetal Coated Colloidosomes as Carriers for an Antibiotic.en
dc.typeArticle
prism.publicationDate2018en
prism.publicationNameFrontiers in chemistryen
prism.startingPage196
prism.volume6en
dc.identifier.doi10.17863/CAM.30529
dcterms.dateAccepted2018-05-15en
rioxxterms.versionofrecord10.3389/fchem.2018.00196en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-01en
dc.contributor.orcidSun, Qian [0000-0002-5192-3599]
dc.contributor.orcidHall, Lisa [0000-0001-9572-9854]
dc.contributor.orcidRouth, Alexander [0000-0002-3443-3053]
dc.identifier.eissn2296-2646
rioxxterms.typeJournal Article/Reviewen


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International