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dc.contributor.authorCannizzaro, Esteren
dc.contributor.authorBannister, Andrewen
dc.contributor.authorHan, Namshiken
dc.contributor.authorAlendar, Andrejen
dc.contributor.authorKouzarides, Tonyen
dc.date.accessioned2018-10-04T09:02:39Z
dc.date.available2018-10-04T09:02:39Z
dc.date.issued2018-06-21en
dc.identifier.issn0014-5793
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283185
dc.description.abstractDDX3X is a multifunctional RNA helicase with documented roles in different cancer types. Here, we demonstrate that DDX3X plays an oncogenic role in breast cancer cells by modulating the cell cycle. Depletion of DDX3X in MCF7 cells slows cell proliferation by inducing a G1 phase arrest. Notably, DDX3X inhibits expression of Kruppel-like factor 4 (KLF4), a transcription factor and cell cycle repressor. Moreover, DDX3X directly interacts with KLF4 mRNA and regulates its splicing. We show that DDX3X-mediated repression of KLF4 promotes expression of S-phase inducing genes in MCF7 breast cancer cells. These findings provide evidence for a novel function of DDX3X in regulating expression and downstream functions of KLF4, a master negative regulator of the cell cycle.
dc.languageengen
dc.publisherWiley-Blackwell
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDDX3Xen
dc.subjectKLF4en
dc.subjectRNA helicaseen
dc.subjectbreast canceren
dc.subjectcell cycleen
dc.titleDDX3X RNA helicase affects breast cancer cell cycle progression by regulating expression of KLF4.en
dc.typeArticle
prism.endingPage2322
prism.issueIdentifier13en
prism.publicationDate2018en
prism.publicationNameFEBS Lettersen
prism.startingPage2308
prism.volume592en
dc.identifier.doi10.17863/CAM.30548
dcterms.dateAccepted2018-05-09en
rioxxterms.versionofrecord10.1002/1873-3468.13106en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2018-06-21en
dc.contributor.orcidBannister, Andrew [0000-0002-6312-4436]
dc.contributor.orcidHan, Namshik [0000-0002-7741-6384]
dc.contributor.orcidKouzarides, Tony [0000-0002-8918-4162]
dc.identifier.eissn1873-3468
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCancer Research UK (10827)
pubs.funder-project-idCancer Research UK (17001)
pubs.funder-project-idWellcome Trust (092096/Z/10/Z)
pubs.funder-project-idCancer Research UK (A14492)
cam.issuedOnline2018-05-21en
dc.identifier.urlhttps://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1873-3468.13106en
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International