Mitochondrial Transcription and Translation: Overview
Essays in Biochemistry
Portland Press, Ltd.
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D'Souza, a., & Minczuk, M. (2018). Mitochondrial Transcription and Translation: Overview. Essays in Biochemistry, 62 309-320. https://doi.org/10.1042/EBC20170102
Mitochondria are the major source of ATP in the cell. Five multi-subunit complexes in the inner membrane of the organelle are involved in the oxidative phosphorylation required for ATP production. Thirteen subunits of these complexes are encoded by the mitochondrial genome often referred to as mtDNA. For this reason, the expression of mtDNA is vital for the assembly and functioning of the oxidative phosphorylation complexes. Defects of the mechanisms regulating mtDNA gene expression have been associated with deficiencies in assembly of these complexes, resulting in mitochondrial diseases. Recently, numerous factors involved in these processes have been identified and characterised leading to a deeper understanding of the mechanisms that underlie mitochondrial diseases.
Medical Research Council (MC_U105697135)
Medical Research Council (MC_UU_00015/4)
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External DOI: https://doi.org/10.1042/EBC20170102
This record's URL: https://www.repository.cam.ac.uk/handle/1810/283188
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/