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dc.contributor.authorVallier, Ludovicen
dc.contributor.authorSegeritz, Charisen
dc.contributor.authorRashid, Sheiikhen
dc.contributor.authorCardoso De Brito, miguelen
dc.contributor.authorMorell, Carolaen
dc.contributor.authorHannan, Nicholasen
dc.contributor.authorGatto, Laurenten
dc.contributor.authorTan, Luen
dc.contributor.authorLilley, Kathrynen
dc.contributor.authorMarciniak, Stefanen
dc.date.accessioned2018-10-05T10:54:30Z
dc.date.available2018-10-05T10:54:30Z
dc.date.issued2018-10-01en
dc.identifier.issn1600-0641
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283206
dc.description.abstractThis study compared the gene expression and protein profiles of healthy liver cells and those affected by the inherited disease α1-antitrypsin deficiency. This approach identified specific factors primarily present in diseased samples which could provide new targets for drug development. This study also demonstrates the interest of using hepatic cells generated from human induced pluripotent stem cells to model liver disease in vitro for uncovering new mechanisms with clinical relevance.
dc.description.sponsorshipCPS is funded through a Children’s Liver Disease Foundation (CLDF) studentship. DAL is funded by the Medical Research Council, Wellcome Trust, GlaxoSmithKline, the Rosetrees Trust, EPSRC and UCLH NIHR Biomedical Research Centre. LV, PM, MCB, NH are funded by ERC Relieve-IMDs and ERC advanced grant New-Chol, Cambridge University Hospitals National Institute for Health Research Biomedical Research Center, and the core support grant from the Wellcome Trust and Medical Research Council to the Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute. STR is funded by an MRC Clinician Scientist Fellowship award.
dc.languageengen
dc.publisherElsevier
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectStemCellInstituteen
dc.subjectHepatocyteen
dc.subjectinherited liver diseaseen
dc.subjecthuman-induced pluripotent stem cellen
dc.subjectα1-Antitrypsin deficiencen
dc.subjectinflammationen
dc.titlehiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiencyen
dc.typeArticle
prism.endingPage860
prism.issueIdentifier4en
prism.publicationDate2018en
prism.publicationNameJournal of Hepatologyen
prism.startingPage851
prism.volume69en
dc.identifier.doi10.17863/CAM.30573
dcterms.dateAccepted2018-05-17en
rioxxterms.versionofrecord10.1016/j.jhep.2018.05.028en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2018-10-01en
dc.contributor.orcidVallier, Ludovic [0000-0002-3848-2602]
dc.contributor.orcidGatto, Laurent [0000-0002-1520-2268]
dc.contributor.orcidLilley, Kathryn [0000-0003-0594-6543]
dc.contributor.orcidMarciniak, Stefan [0000-0001-8472-7183]
dc.identifier.eissn1600-0641
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G1002610)
pubs.funder-project-idMRC (G0601840)
pubs.funder-project-idAlpha One Foundation (unknown)
pubs.funder-project-idMRC (MC_PC_12009)
pubs.funder-project-idNC3Rs (NC/N001540/1)
pubs.funder-project-idNC3Rs (NC/R001987/1)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) ERC (741707)
cam.issuedOnline2018-06-05en
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0168827818321135?via=ihuben


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International