From pulsatile apicomedial contractility to effective epithelial mechanics.
Curr Opin Genet Dev
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Blanchard, G., Étienne, J., & Gorfinkiel, N. (2018). From pulsatile apicomedial contractility to effective epithelial mechanics.. Curr Opin Genet Dev, 51 78-87. https://doi.org/10.1016/j.gde.2018.07.004
We review recent developments in the understanding of the biomechanics of apicomedial actomyosin and how its contractility can tense and deform tissue. Myosin pulses are driven by a biochemical oscillator but how they are modulated by the mechanical context remains unclear. On the other hand, the emergence of tissue behaviour is highly dependent on the material properties of actin, on how strongly components are connected and on the influence of neighbouring tissues. We further review the use of constitutive equations in exploring the mechanics of epithelial apices dominated by apicomedial Myosin contractility.
Epithelium, Humans, Actins, Myosins, Actomyosin, Biomechanical Phenomena
Wellcome Trust (099234/Z/12/Z)
Biotechnology and Biological Sciences Research Council (BB/J010278/1)
External DOI: https://doi.org/10.1016/j.gde.2018.07.004
This record's URL: https://www.repository.cam.ac.uk/handle/1810/283236
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: http://creativecommons.org/licenses/by-nc-nd/4.0/
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