From pulsatile apicomedial contractility to effective epithelial mechanics.
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Authors
Blanchard, Guy B
Étienne, Jocelyn
Gorfinkiel, Nicole
Publication Date
2018-08Journal Title
Curr Opin Genet Dev
ISSN
0959-437X
Publisher
Elsevier BV
Volume
51
Pages
78-87
Language
eng
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Blanchard, G. B., Étienne, J., & Gorfinkiel, N. (2018). From pulsatile apicomedial contractility to effective epithelial mechanics.. Curr Opin Genet Dev, 51 78-87. https://doi.org/10.1016/j.gde.2018.07.004
Abstract
We review recent developments in the understanding of the biomechanics of apicomedial actomyosin and how its contractility can tense and deform tissue. Myosin pulses are driven by a biochemical oscillator but how they are modulated by the mechanical context remains unclear. On the other hand, the emergence of tissue behaviour is highly dependent on the material properties of actin, on how strongly components are connected and on the influence of neighbouring tissues. We further review the use of constitutive equations in exploring the mechanics of epithelial apices dominated by apicomedial Myosin contractility.
Keywords
Actins, Actomyosin, Biomechanical Phenomena, Epithelium, Humans, Myosins
Sponsorship
Wellcome Trust (099234/Z/12/Z)
Biotechnology and Biological Sciences Research Council (BB/J010278/1)
Identifiers
External DOI: https://doi.org/10.1016/j.gde.2018.07.004
This record's URL: https://www.repository.cam.ac.uk/handle/1810/283236
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: http://creativecommons.org/licenses/by-nc-nd/4.0/
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