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dc.contributor.authorExton-McGuinness, Marc TJen
dc.contributor.authorMilton, Amyen
dc.date.accessioned2018-10-10T05:14:54Z
dc.date.available2018-10-10T05:14:54Z
dc.date.issued2018-09en
dc.identifier.issn1072-0502
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283285
dc.description.abstractAddiction is a chronic, relapsing disorder. The progression to pathological drug-seeking is thought to be driven by maladaptive learning processes which store and maintain associative memory, linking drug highs with cues and actions in the environment. These memories can encode pavlovian associations which link predictive stimuli (e.g. people, places and paraphernalia) with a hedonic drug high, as well as instrumental learning about the actions required to obtain drug-associated incentives. Learned memories are not permanent however, and much recent interest has been generated in exploiting the process of reconsolidation to erase or significantly weaken maladaptive memories to treat several mental health disorders, including addictions. Normally reconsolidation serves to update and maintain the adaptive relevance of memories, however administration of amnestic agents within the critical ‘reconsolidation window’ can weaken or even erase the maladaptive memories. Here we discuss recent advances in the field, including ongoing efforts to translate preclinical reconsolidation research in animal models into clinical practice.
dc.format.mediumElectronic-Printen
dc.languageengen
dc.publisherCold Spring Harbor Laboratory Press
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectSubstance-Related Disordersen
dc.subjectConditioning, Classicalen
dc.subjectConditioning, Operanten
dc.subjectSecondary Preventionen
dc.subjectMemory Consolidationen
dc.titleReconsolidation blockade for the treatment of addiction: challenges, new targets, and opportunities.en
dc.typeArticle
prism.endingPage500
prism.issueIdentifier9en
prism.publicationDate2018en
prism.publicationNameLearning & memory (Cold Spring Harbor, N.Y.)en
prism.startingPage492
prism.volume25en
dc.identifier.doi10.17863/CAM.30653
dcterms.dateAccepted2018-05-21en
rioxxterms.versionofrecord10.1101/lm.046771.117en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-09en
dc.contributor.orcidExton-McGuinness, Marc TJ [0000-0002-6851-9306]
dc.contributor.orcidMilton, Amy [0000-0003-0175-9417]
dc.identifier.eissn1549-5485
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (200710/Z/16/Z)
pubs.funder-project-idMRC (MR/N02530X/1)
rioxxterms.freetoread.startdate2019-09-30


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