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dc.contributor.authorGalluzzi, Lorenzo
dc.contributor.authorVitale, Ilio
dc.contributor.authorAaronson, Stuart A
dc.contributor.authorAbrams, John M
dc.contributor.authorAdam, Dieter
dc.contributor.authorAgostinis, Patrizia
dc.contributor.authorAlnemri, Emad S
dc.contributor.authorAltucci, Lucia
dc.contributor.authorAmelio, Ivano
dc.contributor.authorAndrews, David W
dc.contributor.authorAnnicchiarico-Petruzzelli, Margherita
dc.contributor.authorAntonov, Alexey V
dc.contributor.authorArama, Eli
dc.contributor.authorBaehrecke, Eric H
dc.contributor.authorBarlev, Nickolai A
dc.contributor.authorBazan, Nicolas G
dc.contributor.authorBernassola, Francesca
dc.contributor.authorBertrand, Mathieu JM
dc.contributor.authorBianchi, Katiuscia
dc.contributor.authorBlagosklonny, Mikhail V
dc.contributor.authorBlomgren, Klas
dc.contributor.authorBorner, Christoph
dc.contributor.authorBoya, Patricia
dc.contributor.authorBrenner, Catherine
dc.contributor.authorCampanella, Michelangelo
dc.contributor.authorCandi, Eleonora
dc.contributor.authorCarmona-Gutierrez, Didac
dc.contributor.authorCecconi, Francesco
dc.contributor.authorChan, Francis K-M
dc.contributor.authorChandel, Navdeep S
dc.contributor.authorCheng, Emily H
dc.contributor.authorChipuk, Jerry E
dc.contributor.authorCidlowski, John A
dc.contributor.authorCiechanover, Aaron
dc.contributor.authorCohen, Gerald M
dc.contributor.authorConrad, Marcus
dc.contributor.authorCubillos-Ruiz, Juan R
dc.contributor.authorCzabotar, Peter E
dc.contributor.authorD'Angiolella, Vincenzo
dc.contributor.authorDawson, Ted M
dc.contributor.authorDawson, Valina L
dc.contributor.authorDe Laurenzi, Vincenzo
dc.contributor.authorDe Maria, Ruggero
dc.contributor.authorDebatin, Klaus-Michael
dc.contributor.authorDeBerardinis, Ralph J
dc.contributor.authorDeshmukh, Mohanish
dc.contributor.authorDi Daniele, Nicola
dc.contributor.authorDi Virgilio, Francesco
dc.contributor.authorDixit, Vishva M
dc.contributor.authorDixon, Scott J
dc.contributor.authorDuckett, Colin S
dc.contributor.authorDynlacht, Brian D
dc.contributor.authorEl-Deiry, Wafik S
dc.contributor.authorElrod, John W
dc.contributor.authorFimia, Gian Maria
dc.contributor.authorFulda, Simone
dc.contributor.authorGarcía-Sáez, Ana J
dc.contributor.authorGarg, Abhishek D
dc.contributor.authorGarrido, Carmen
dc.contributor.authorGavathiotis, Evripidis
dc.contributor.authorGolstein, Pierre
dc.contributor.authorGottlieb, Eyal
dc.contributor.authorGreen, Douglas R
dc.contributor.authorGreene, Lloyd A
dc.contributor.authorGronemeyer, Hinrich
dc.contributor.authorGross, Atan
dc.contributor.authorHajnoczky, Gyorgy
dc.contributor.authorHardwick, J Marie
dc.contributor.authorHarris, Isaac S
dc.contributor.authorHengartner, Michael O
dc.contributor.authorHetz, Claudio
dc.contributor.authorIchijo, Hidenori
dc.contributor.authorJäättelä, Marja
dc.contributor.authorJoseph, Bertrand
dc.contributor.authorJost, Philipp J
dc.contributor.authorJuin, Philippe P
dc.contributor.authorKaiser, William J
dc.contributor.authorKarin, Michael
dc.contributor.authorKaufmann, Thomas
dc.contributor.authorKepp, Oliver
dc.contributor.authorKimchi, Adi
dc.contributor.authorKitsis, Richard N
dc.contributor.authorKlionsky, Daniel J
dc.contributor.authorKnight, Richard A
dc.contributor.authorKumar, Sharad
dc.contributor.authorLee, Sam W
dc.contributor.authorLemasters, John J
dc.contributor.authorLevine, Beth
dc.contributor.authorLinkermann, Andreas
dc.contributor.authorLipton, Stuart A
dc.contributor.authorLockshin, Richard A
dc.contributor.authorLópez-Otín, Carlos
dc.contributor.authorLowe, Scott W
dc.contributor.authorLuedde, Tom
dc.contributor.authorLugli, Enrico
dc.contributor.authorMacFarlane, Marion
dc.contributor.authorMadeo, Frank
dc.contributor.authorMalewicz, Michal
dc.contributor.authorMalorni, Walter
dc.contributor.authorManic, Gwenola
dc.contributor.authorMarine, Jean-Christophe
dc.contributor.authorMartin, Seamus J
dc.contributor.authorMartinou, Jean-Claude
dc.contributor.authorMedema, Jan Paul
dc.contributor.authorMehlen, Patrick
dc.contributor.authorMeier, Pascal
dc.contributor.authorMelino, Sonia
dc.contributor.authorMiao, Edward A
dc.contributor.authorMolkentin, Jeffery D
dc.contributor.authorMoll, Ute M
dc.contributor.authorMuñoz-Pinedo, Cristina
dc.contributor.authorNagata, Shigekazu
dc.contributor.authorNuñez, Gabriel
dc.contributor.authorOberst, Andrew
dc.contributor.authorOren, Moshe
dc.contributor.authorOverholtzer, Michael
dc.contributor.authorPagano, Michele
dc.contributor.authorPanaretakis, Theocharis
dc.contributor.authorPasparakis, Manolis
dc.contributor.authorPenninger, Josef M
dc.contributor.authorPereira, David M
dc.contributor.authorPervaiz, Shazib
dc.contributor.authorPeter, Marcus E
dc.contributor.authorPiacentini, Mauro
dc.contributor.authorPinton, Paolo
dc.contributor.authorPrehn, Jochen HM
dc.contributor.authorPuthalakath, Hamsa
dc.contributor.authorRabinovich, Gabriel A
dc.contributor.authorRehm, Markus
dc.contributor.authorRizzuto, Rosario
dc.contributor.authorRodrigues, Cecilia MP
dc.contributor.authorRubinsztein, David C
dc.contributor.authorRudel, Thomas
dc.contributor.authorRyan, Kevin M
dc.contributor.authorSayan, Emre
dc.contributor.authorScorrano, Luca
dc.contributor.authorShao, Feng
dc.contributor.authorShi, Yufang
dc.contributor.authorSilke, John
dc.contributor.authorSimon, Hans-Uwe
dc.contributor.authorSistigu, Antonella
dc.contributor.authorStockwell, Brent R
dc.contributor.authorStrasser, Andreas
dc.contributor.authorSzabadkai, Gyorgy
dc.contributor.authorTait, Stephen WG
dc.contributor.authorTang, Daolin
dc.contributor.authorTavernarakis, Nektarios
dc.contributor.authorThorburn, Andrew
dc.contributor.authorTsujimoto, Yoshihide
dc.contributor.authorTurk, Boris
dc.contributor.authorVanden Berghe, Tom
dc.contributor.authorVandenabeele, Peter
dc.contributor.authorVander Heiden, Matthew G
dc.contributor.authorVillunger, Andreas
dc.contributor.authorVirgin, Herbert W
dc.contributor.authorVousden, Karen H
dc.contributor.authorVucic, Domagoj
dc.contributor.authorWagner, Erwin F
dc.contributor.authorWalczak, Henning
dc.contributor.authorWallach, David
dc.contributor.authorWang, Ying
dc.contributor.authorWells, James A
dc.contributor.authorWood, Will
dc.contributor.authorYuan, Junying
dc.contributor.authorZakeri, Zahra
dc.contributor.authorZhivotovsky, Boris
dc.contributor.authorZitvogel, Laurence
dc.contributor.authorMelino, Gerry
dc.contributor.authorKroemer, Guido
dc.date.accessioned2018-10-10T05:15:36Z
dc.date.available2018-10-10T05:15:36Z
dc.date.issued2018-03
dc.identifier.issn1350-9047
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283310
dc.description.abstractOver the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectLysosomes
dc.subjectAnimals
dc.subjectHumans
dc.subjectNecrosis
dc.subjectMitochondrial Membrane Transport Proteins
dc.subjectCell Death
dc.subjectMitochondrial Permeability Transition Pore
dc.titleMolecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
dc.typeArticle
prism.endingPage541
prism.issueIdentifier3
prism.publicationDate2018
prism.publicationNameCell Death Differ
prism.startingPage486
prism.volume25
dc.identifier.doi10.17863/CAM.30678
dcterms.dateAccepted2017-10-13
rioxxterms.versionofrecord10.1038/s41418-017-0012-4
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-03
dc.contributor.orcidAmelio, Ivano [0000-0002-9126-5391]
dc.contributor.orcidRubinsztein, David [0000-0001-5002-5263]
dc.contributor.orcidMelino, Gerry [0000-0001-9428-5972]
dc.identifier.eissn1476-5403
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-01-23


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