Actin cages isolate damaged mitochondria during mitophagy.
Informa UK Limited
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Kruppa, A., & Buss, F. (2018). Actin cages isolate damaged mitochondria during mitophagy.. Autophagy, 14 (9), 1644-1645. https://doi.org/10.1080/15548627.2018.1486152
Mitochondrial homeostasis is maintained by removing dysfunctional, ubiquitinated mitochondria from the network via PRKN-dependent mitophagy. MYO6, a unique myosin that moves towards the minus ends of actin filaments, forms a complex with PRKN and is selectively recruited to damaged mitochondria by binding to ubiquitin. On the mitochondrial surface, this myosin motor initiates the assembly of F-actin cages, which serve as a quality control mechanism to isolate dysfunctional mitochondria thereby preventing their refusion with neighboring populations. MYO6 also plays a role in the later stages of the mitophagy pathway by tethering endosomes to actin filaments facilitating mitophagosome maturation and autophagosome-lysosome fusion.
Hela Cells, Mitochondria, Humans, Actins, Ubiquitin-Protein Ligases, Myosin Heavy Chains, Autophagy, Mitophagy
British Heart Foundation (PG/15/12/31280)
Medical Research Council (MR/N000048/1)
Medical Research Council (MR/K000888/1)
Michael J Fox Foundation (MJFF) (15669)
External DOI: https://doi.org/10.1080/15548627.2018.1486152
This record's URL: https://www.repository.cam.ac.uk/handle/1810/283371