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dc.contributor.authorKruppa, Antonina
dc.contributor.authorBuss, Folma
dc.date.accessioned2018-10-10T05:17:20Z
dc.date.available2018-10-10T05:17:20Z
dc.date.issued2018
dc.identifier.issn1554-8627
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283371
dc.description.abstractMitochondrial homeostasis is maintained by removing dysfunctional, ubiquitinated mitochondria from the network via PRKN-dependent mitophagy. MYO6, a unique myosin that moves towards the minus ends of actin filaments, forms a complex with PRKN and is selectively recruited to damaged mitochondria by binding to ubiquitin. On the mitochondrial surface, this myosin motor initiates the assembly of F-actin cages, which serve as a quality control mechanism to isolate dysfunctional mitochondria thereby preventing their refusion with neighboring populations. MYO6 also plays a role in the later stages of the mitophagy pathway by tethering endosomes to actin filaments facilitating mitophagosome maturation and autophagosome-lysosome fusion.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherInforma UK Limited
dc.subjectHela Cells
dc.subjectMitochondria
dc.subjectHumans
dc.subjectActins
dc.subjectUbiquitin-Protein Ligases
dc.subjectMyosin Heavy Chains
dc.subjectAutophagy
dc.subjectMitophagy
dc.titleActin cages isolate damaged mitochondria during mitophagy.
dc.typeArticle
prism.endingPage1645
prism.issueIdentifier9
prism.publicationDate2018
prism.publicationNameAutophagy
prism.startingPage1644
prism.volume14
dc.identifier.doi10.17863/CAM.30739
dcterms.dateAccepted2018-05-30
rioxxterms.versionofrecord10.1080/15548627.2018.1486152
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-01
dc.contributor.orcidBuss, Folma [0000-0003-4457-3479]
dc.identifier.eissn1554-8635
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBritish Heart Foundation (PG/15/12/31280)
pubs.funder-project-idMedical Research Council (MR/N000048/1)
pubs.funder-project-idMedical Research Council (MR/K000888/1)
pubs.funder-project-idMichael J Fox Foundation (MJFF) (15669)
cam.issuedOnline2018-07-29
rioxxterms.freetoread.startdate2019-07-29


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