Actin cages isolate damaged mitochondria during mitophagy.
dc.contributor.author | Kruppa, Antonina J | |
dc.contributor.author | Buss, Folma | |
dc.date.accessioned | 2018-10-10T05:17:20Z | |
dc.date.available | 2018-10-10T05:17:20Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1554-8627 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/283371 | |
dc.description.abstract | Mitochondrial homeostasis is maintained by removing dysfunctional, ubiquitinated mitochondria from the network via PRKN-dependent mitophagy. MYO6, a unique myosin that moves towards the minus ends of actin filaments, forms a complex with PRKN and is selectively recruited to damaged mitochondria by binding to ubiquitin. On the mitochondrial surface, this myosin motor initiates the assembly of F-actin cages, which serve as a quality control mechanism to isolate dysfunctional mitochondria thereby preventing their refusion with neighboring populations. MYO6 also plays a role in the later stages of the mitophagy pathway by tethering endosomes to actin filaments facilitating mitophagosome maturation and autophagosome-lysosome fusion. | |
dc.format.medium | Print-Electronic | |
dc.language | eng | |
dc.publisher | Informa UK Limited | |
dc.subject | Hela Cells | |
dc.subject | Mitochondria | |
dc.subject | Humans | |
dc.subject | Actins | |
dc.subject | Ubiquitin-Protein Ligases | |
dc.subject | Myosin Heavy Chains | |
dc.subject | Autophagy | |
dc.subject | Mitophagy | |
dc.title | Actin cages isolate damaged mitochondria during mitophagy. | |
dc.type | Article | |
prism.endingPage | 1645 | |
prism.issueIdentifier | 9 | |
prism.publicationDate | 2018 | |
prism.publicationName | Autophagy | |
prism.startingPage | 1644 | |
prism.volume | 14 | |
dc.identifier.doi | 10.17863/CAM.30739 | |
dcterms.dateAccepted | 2018-05-30 | |
rioxxterms.versionofrecord | 10.1080/15548627.2018.1486152 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2018-01 | |
dc.contributor.orcid | Buss, Folma [0000-0003-4457-3479] | |
dc.identifier.eissn | 1554-8635 | |
rioxxterms.type | Journal Article/Review | |
pubs.funder-project-id | British Heart Foundation (PG/15/12/31280) | |
pubs.funder-project-id | Medical Research Council (MR/N000048/1) | |
pubs.funder-project-id | Medical Research Council (MR/K000888/1) | |
pubs.funder-project-id | Michael J Fox Foundation (MJFF) (15669) | |
cam.issuedOnline | 2018-07-29 | |
rioxxterms.freetoread.startdate | 2019-07-29 |
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