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dc.contributor.authorRitson, Dougal J
dc.contributor.authorBattilocchio, Claudio
dc.contributor.authorLey, Steven
dc.contributor.authorSutherland, John D
dc.date.accessioned2018-10-10T05:19:04Z
dc.date.available2018-10-10T05:19:04Z
dc.date.issued2018-05-08
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283434
dc.description.abstractWhen considering life's aetiology, the first questions that must be addressed are "how?" and "where?" were ostensibly complex molecules, considered necessary for life's beginning, constructed from simpler, more abundant feedstock molecules on primitive Earth. Previously, we have used multiple clues from the prebiotic synthetic requirements of (proto)biomolecules to pinpoint a set of closely related geochemical scenarios that are suggestive of flow and semi-batch chemistries. We now wish to report a multistep, uninterrupted synthesis of a key heterocycle (2-aminooxazole) en route to activated nucleotides starting from highly plausible, prebiotic feedstock molecules under conditions which mimic this scenario. Further consideration of the scenario has uncovered additional pertinent and novel aspects of prebiotic chemistry, which greatly enhance the efficiency and plausibility of the synthesis.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAldehydes
dc.subjectOxazoles
dc.subjectMolecular Mimicry
dc.subjectSurface Properties
dc.subjectPhysical Phenomena
dc.subjectPhotochemical Processes
dc.subjectOrigin of Life
dc.subjectEarth, Planet
dc.titleMimicking the surface and prebiotic chemistry of early Earth using flow chemistry.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2018
prism.publicationNameNat Commun
prism.startingPage1821
prism.volume9
dc.identifier.doi10.17863/CAM.30801
dcterms.dateAccepted2018-04-06
rioxxterms.versionofrecord10.1038/s41467-018-04147-2
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-05-08
dc.contributor.orcidRitson, Dougal J [0000-0002-0517-2747]
dc.contributor.orcidBattilocchio, Claudio [0000-0002-4601-8527]
dc.contributor.orcidLey, Steven [0000-0002-7816-0042]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/K009494/1)
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/M004120/1)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (737266)
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/K039520/1)
cam.issuedOnline2018-05-08


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International