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dc.contributor.authorCherskov, Adriana
dc.contributor.authorPohl, Alexa
dc.contributor.authorAllison, Carrie
dc.contributor.authorZhang, Heping
dc.contributor.authorPayne, Rupert A
dc.contributor.authorBaron-Cohen, Simon
dc.date.accessioned2018-10-10T05:19:13Z
dc.date.available2018-10-10T05:19:13Z
dc.date.issued2018-08-01
dc.identifier.issn2158-3188
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283440
dc.description.abstractElevated levels of prenatal testosterone may increase the risk for autism spectrum conditions (autism). Given that polycystic ovary syndrome (PCOS) is also associated with elevated prenatal testosterone and its precursor sex steroids, a hypothesis from the prenatal sex steroid theory is that women with PCOS should have elevated autistic traits and a higher rate of autism among their children. Using electronic health records obtained from the Clinical Practice Research Datalink (CPRD) in the UK between 1990 and 2014, we conducted three matched case-control studies. Studies 1 and 2 examined the risk of PCOS in women with autism (n = 971) and the risk of autism in women with PCOS (n = 26,263), respectively, compared with matched controls. Study 3 examined the odds ratio (OR) of autism in first-born children of women with PCOS (n = 8588), matched to 41,127 controls. In Studies 1 and 2 we found increased prevalence of PCOS in women with autism (2.3% vs. 1.1%; unadjusted OR: 2.01, 95% CI: 1.22-3.30) and elevated rates of autism in women with PCOS (0.17% vs. 0.09%, unadjusted OR: 1.94 CI: 1.37-2.76). In Study 3 we found the odds of having a child with autism were significantly increased, even after adjustment for maternal psychiatric diagnoses, obstetric complications, and maternal metabolic conditions (unadjusted OR: 1.60, 95% CI: 1.28-2.00; adjusted OR: 1.35, 95% CI: 1.06-1.73). These studies provide further evidence that women with PCOS and their children have a greater risk of autism.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectPolycystic Ovary Syndrome
dc.subjectPregnancy Complications
dc.subjectTestosterone
dc.subjectLogistic Models
dc.subjectRisk Assessment
dc.subjectCase-Control Studies
dc.subjectMothers
dc.subjectPregnancy
dc.subjectAdolescent
dc.subjectAdult
dc.subjectChild
dc.subjectFemale
dc.subjectMale
dc.subjectYoung Adult
dc.subjectAutism Spectrum Disorder
dc.subjectUnited Kingdom
dc.titlePolycystic ovary syndrome and autism: A test of the prenatal sex steroid theory.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2018
prism.publicationNameTransl Psychiatry
prism.startingPage136
prism.volume8
dc.identifier.doi10.17863/CAM.30807
dcterms.dateAccepted2018-06-08
rioxxterms.versionofrecord10.1038/s41398-018-0186-7
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-08
dc.contributor.orcidAllison, Carrie [0000-0003-2272-2090]
dc.contributor.orcidBaron-Cohen, Simon [0000-0001-9217-2544]
dc.identifier.eissn2158-3188
rioxxterms.typeJournal Article/Review
pubs.funder-project-idAutism Research Trust (unknown)
pubs.funder-project-idMedical Research Council (G0600977)
cam.issuedOnline2018-08-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International