New Insights Into the Regulation of Natural-Killer Group 2 Member D (NKG2D) and NKG2D-Ligands: Endoplasmic Reticulum Stress and CEA-Related Cell Adhesion Molecule 1
dc.contributor.author | Kaser, Arthur | |
dc.contributor.author | Hosomi, Shuhei | |
dc.contributor.author | Grootjans, Joep | |
dc.contributor.author | Huang, Yu-Hwa | |
dc.contributor.author | Blumberg, Richard S | |
dc.date.accessioned | 2018-10-10T09:15:27Z | |
dc.date.available | 2018-10-10T09:15:27Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1664-3224 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/283494 | |
dc.description.abstract | Natural-killer group 2 member D (NKG2D) is a well-characterized activating receptor expressed by natural killer (NK) cells, NKT cells, activated CD8+ T cells, subsets of γδ+ T cells, and innate-like T cells. NKG2D recognizes multiple ligands (NKG2D-ligands) to mount an innate immune response against stressed, transformed or infected cells. NKG2D-ligand surface expression is tightly restricted on healthy cells through transcriptional and post-transcriptional mechanisms, while transformed or infected cells express the ligands as a danger signal. Recent studies have revealed that unfolded protein response (UPR) pathways during endoplasmic reticulum (ER) stress result in up-regulation of ULBP-related protein via the PERK-ATF4-CHOP pathway, which can be linked to the pathogenesis of autoimmune diseases. Transformed cells however possess mechanisms to escape NKG2D-mediated immune surveillance, such as upregulation of carcinoembryonic antigen (CEA)-related cell adhesion molecule 1 (CEACAM1), a negative regulator of NKG2D-ligands. In this review, we discuss mechanisms of NKG2D-ligand regulation, with a focus on newly discovered mechanisms that promote NKG2D-ligand expression on epithelial cells, including ER stress, and mechanisms that suppress NKG2D-ligand mediated killing of cancer cells, namely by co-expression of CEACAM1. | |
dc.description.sponsorship | Wellcome Trust Senior Investigator Award 106260/Z/14/Z, the European Research Council HORIZON2020/ERC grant no. 648889 (A.K.) | |
dc.language | eng | |
dc.publisher | Frontiers Media | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | natural-killer group 2 member D | |
dc.subject | natural-killer group 2 member D-ligand | |
dc.subject | murine UL16-binding protein like transcript 1 | |
dc.subject | UL16 binding protein 1 | |
dc.subject | endoplasmic reticulum stress | |
dc.subject | CEA-related cell adhesion molecule 1 | |
dc.title | New Insights Into the Regulation of Natural-Killer Group 2 Member D (NKG2D) and NKG2D-Ligands: Endoplasmic Reticulum Stress and CEA-Related Cell Adhesion Molecule 1 | |
dc.type | Article | |
prism.number | 1324 | |
prism.publicationName | Frontiers in Immunology | |
prism.volume | 9 | |
dc.identifier.doi | 10.17863/CAM.30858 | |
dcterms.dateAccepted | 2018-05-28 | |
rioxxterms.versionofrecord | 10.3389/fimmu.2018.01324 | |
rioxxterms.version | VoR | |
rioxxterms.licenseref.uri | http://creativecommons.org/licenses/by/4.0/ | |
rioxxterms.licenseref.startdate | 2018-05-28 | |
dc.identifier.eissn | 1664-3224 | |
rioxxterms.type | Journal Article/Review | |
pubs.funder-project-id | Wellcome Trust (106260/Z/14/Z) | |
pubs.funder-project-id | European Research Council (648889) | |
cam.issuedOnline | 2018-06-18 | |
rioxxterms.freetoread.startdate | 2100-01-01 |
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