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dc.contributor.authorvan Zuydam, Natalie R
dc.contributor.authorAhlqvist, Emma
dc.contributor.authorSandholm, Niina
dc.contributor.authorDeshmukh, Harshal
dc.contributor.authorRayner, N William
dc.contributor.authorAbdalla, Moustafa
dc.contributor.authorLadenvall, Claes
dc.contributor.authorZiemek, Daniel
dc.contributor.authorFauman, Eric
dc.contributor.authorRobertson, Neil R
dc.contributor.authorMcKeigue, Paul M
dc.contributor.authorValo, Erkka
dc.contributor.authorForsblom, Carol
dc.contributor.authorHarjutsalo, Valma
dc.contributor.authorFinnish Diabetic Nephropathy Study (FinnDiane)
dc.contributor.authorPerna, Annalisa
dc.contributor.authorRurali, Erica
dc.contributor.authorMarcovecchio, Loredana
dc.contributor.authorIgo, Robert P
dc.contributor.authorSalem, Rany M
dc.contributor.authorPerico, Norberto
dc.contributor.authorLajer, Maria
dc.contributor.authorKäräjämäki, Annemari
dc.contributor.authorImamura, Minako
dc.contributor.authorKubo, Michiaki
dc.contributor.authorTakahashi, Atsushi
dc.contributor.authorSim, Xueling
dc.contributor.authorLiu, Jianjun
dc.contributor.authorvan Dam, Rob M
dc.contributor.authorJiang, Guozhi
dc.contributor.authorTam, Claudia HT
dc.contributor.authorLuk, Andrea OY
dc.contributor.authorLee, Heung Man
dc.contributor.authorLim, Cadmon KP
dc.contributor.authorSzeto, Cheuk Chun
dc.contributor.authorSo, Wing Yee
dc.contributor.authorChan, Juliana CN
dc.contributor.authorHong Kong Diabetes Registry Theme-based Research Scheme Project Group
dc.contributor.authorAng, Su Fen
dc.contributor.authorDorajoo, Rajkumar
dc.contributor.authorWang, Ling
dc.contributor.authorClara, Tan Si Hua
dc.contributor.authorMcKnight, Amy-Jayne
dc.contributor.authorDuffy, Seamus
dc.contributor.authorWarren 3 and Genetics of Kidneys in Diabetes (GoKinD) Study Group
dc.contributor.authorPezzolesi, Marcus G
dc.contributor.authorGENIE (GEnetics of Nephropathy an International Effort) Consortium
dc.contributor.authorMarre, Michel
dc.contributor.authorGyorgy, Beata
dc.contributor.authorHadjadj, Samy
dc.contributor.authorHiraki, Linda T
dc.contributor.authorDiabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group
dc.contributor.authorAhluwalia, Tarunveer S
dc.contributor.authorAlmgren, Peter
dc.contributor.authorSchulz, Christina-Alexandra
dc.contributor.authorOrho-Melander, Marju
dc.contributor.authorLinneberg, Allan
dc.contributor.authorChristensen, Cramer
dc.contributor.authorWitte, Daniel R
dc.contributor.authorGrarup, Niels
dc.contributor.authorBrandslund, Ivan
dc.contributor.authorMelander, Olle
dc.contributor.authorPaterson, Andrew D
dc.contributor.authorTregouet, David
dc.contributor.authorMaxwell, Alexander P
dc.contributor.authorLim, Su Chi
dc.contributor.authorMa, Ronald CW
dc.contributor.authorTai, E Shyong
dc.contributor.authorMaeda, Shiro
dc.contributor.authorLyssenko, Valeriya
dc.contributor.authorTuomi, Tiinamaija
dc.contributor.authorKrolewski, Andrzej S
dc.contributor.authorRich, Stephen S
dc.contributor.authorHirschhorn, Joel N
dc.contributor.authorFlorez, Jose C
dc.contributor.authorDunger, David
dc.contributor.authorPedersen, Oluf
dc.contributor.authorHansen, Torben
dc.contributor.authorRossing, Peter
dc.contributor.authorRemuzzi, Giuseppe
dc.contributor.authorSUrrogate markers for Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT) Consortium
dc.contributor.authorBrosnan, Mary Julia
dc.contributor.authorPalmer, Colin NA
dc.contributor.authorGroop, Per-Henrik
dc.contributor.authorColhoun, Helen M
dc.contributor.authorGroop, Leif C
dc.contributor.authorMcCarthy, Mark I
dc.date.accessioned2018-10-10T10:45:30Z
dc.date.available2018-10-10T10:45:30Z
dc.date.issued2018-07
dc.identifier.issn0012-1797
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283546
dc.description.abstractIdentification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 × 10-8) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherAmerican Diabetes Association
dc.subjectFinnish Diabetic Nephropathy Study (FinnDiane)
dc.subjectHong Kong Diabetes Registry Theme-based Research Scheme Project Group
dc.subjectWarren 3 and Genetics of Kidneys in Diabetes (GoKinD) Study Group
dc.subjectGENIE (GEnetics of Nephropathy an International Effort) Consortium
dc.subjectDiabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group
dc.subjectSUrrogate markers for Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT) Consortium
dc.subjectHumans
dc.subjectDiabetic Nephropathies
dc.subjectKidney Failure, Chronic
dc.subjectDiabetes Mellitus, Type 2
dc.subjectGenetic Predisposition to Disease
dc.subjectCase-Control Studies
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectRenal Insufficiency, Chronic
dc.subjectGenome-Wide Association Study
dc.titleA Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.
dc.typeArticle
prism.endingPage1427
prism.issueIdentifier7
prism.publicationDate2018
prism.publicationNameDiabetes
prism.startingPage1414
prism.volume67
dc.identifier.doi10.17863/CAM.30909
dcterms.dateAccepted2018-03-30
rioxxterms.versionofrecord10.2337/db17-0914
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-07
dc.contributor.orcidvan Zuydam, Natalie R [0000-0002-9809-1398]
dc.contributor.orcidSandholm, Niina [0000-0003-4322-6942]
dc.contributor.orcidMarcovecchio, Loredana [0000-0002-4415-316X]
dc.contributor.orcidDunger, David [0000-0002-2566-9304]
dc.contributor.orcidGroop, Per-Henrik [0000-0003-4055-6954]
dc.contributor.orcidColhoun, Helen M [0000-0002-8345-3288]
dc.identifier.eissn1939-327X
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-04-27
rioxxterms.freetoread.startdate2019-07-31


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