Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole.

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Authors
Kadirvel, Manikandan
Cardoso, Déborah
Freeman, Sally
  Brown, Gavin
Publication Date
2018
Journal Title
J Radioanal Nucl Chem
ISSN
0236-5731
Publisher
Springer Science and Business Media LLC
Volume
317
Issue
2
Pages
977-984
Language
eng
Type
Article
Physical Medium
Print-Electronic
Metadata
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Citation
Kadirvel, M., Cardoso, D., Freeman, S., & Brown, G. (2018). Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole.. J Radioanal Nucl Chem, 317 (2), 977-984. https://doi.org/10.1007/s10967-018-5948-4
Abstract
N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of N-[11C]methyl carbamoylimidazole as a new [11C]synthon to radiolabel biomolecules for PET imaging research. N-[11C]methyl carbamoylimidazole was prepared from [11C]methyl iodide in 70-74% radiochemical yield (decay corrected) and can be used in situ for further reaction without purification. The reactivity of N-[11C]methyl carbamoylimidazole was demonstrated in a series of [11C]carbamoylation reactions.
Keywords
11C, Carbamoylation, Methyl isocyanate, PET, Radiochemistry
Identifiers
External DOI: https://doi.org/10.1007/s10967-018-5948-4
This record's URL: https://www.repository.cam.ac.uk/handle/1810/283581
Rights
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International