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dc.contributor.authorKadirvel, Manikandan
dc.contributor.authorCardoso, Déborah
dc.contributor.authorFreeman, Sally
dc.contributor.authorBrown, Gavin
dc.date.accessioned2018-10-10T17:30:50Z
dc.date.available2018-10-10T17:30:50Z
dc.date.issued2018
dc.identifier.issn0236-5731
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283581
dc.description.abstractN-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of N-[11C]methyl carbamoylimidazole as a new [11C]synthon to radiolabel biomolecules for PET imaging research. N-[11C]methyl carbamoylimidazole was prepared from [11C]methyl iodide in 70-74% radiochemical yield (decay corrected) and can be used in situ for further reaction without purification. The reactivity of N-[11C]methyl carbamoylimidazole was demonstrated in a series of [11C]carbamoylation reactions.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleRadiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole.
dc.typeArticle
prism.endingPage984
prism.issueIdentifier2
prism.publicationDate2018
prism.publicationNameJ Radioanal Nucl Chem
prism.startingPage977
prism.volume317
dc.identifier.doi10.17863/CAM.30943
rioxxterms.versionofrecord10.1007/s10967-018-5948-4
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-01
dc.contributor.orcidBrown, Gavin [0000-0003-4443-0785]
dc.identifier.eissn1588-2780
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-06-19


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International