Show simple item record

dc.contributor.authorErmakova, Anna O
dc.contributor.authorKnolle, Franziska
dc.contributor.authorJusticia, Azucena
dc.contributor.authorBullmore, Edward
dc.contributor.authorJones, Peter
dc.contributor.authorRobbins, Trevor
dc.contributor.authorFletcher, Paul
dc.contributor.authorMurray, Graham
dc.date.accessioned2018-06-04T11:51:44Z
dc.date.accessioned2018-10-15T11:24:01Z
dc.date.available2018-06-04T11:51:44Z
dc.date.available2018-10-15T11:24:01Z
dc.date.issued2018-07
dc.identifier.issn0893-133X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283629
dc.description.abstractOngoing research suggests preliminary, though not entirely consistent, evidence of neural abnormalities in signalling prediction errors in schizophrenia. Supporting theories suggest mechanistic links between the disruption of these processes and the generation of psychotic symptoms. However, it is unknown at what stage in the pathogenesis of psychosis these impairments in prediction-error signalling develop. One major confound in prior studies is the use of medicated patients with strongly varying disease durations. Our study aims to investigate the involvement of the meso-cortico-striatal circuitry during reward prediction-error signalling in earliest stages of psychosis. We studied patients with first-episode psychosis (FEP) and help-seeking individuals at-risk for psychosis due to sub-threshold prodromal psychotic symptoms. Patients with either FEP (n = 14), or at-risk for developing psychosis (n = 30), and healthy volunteers (n = 39) performed a reinforcement learning task during fMRI scanning. ANOVA revealed significant (p < 0.05 family-wise error corrected) prediction-error signalling differences between groups in the dopaminergic midbrain and right middle frontal gyrus (dorsolateral prefrontal cortex, DLPFC). FEP patients showed disrupted reward prediction-error signalling compared to controls in both regions. At-risk patients showed intermediate activation in the midbrain that significantly differed from controls and from FEP patients, but DLPFC activation that did not differ from controls. Our study confirms that FEP patients have abnormal meso-cortical signalling of reward-prediction errors, whereas reward-prediction-error dysfunction in the at-risk patients appears to show a more nuanced pattern of activation with a degree of midbrain impairment but preserved cortical function.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.replaceshttps://www.repository.cam.ac.uk/handle/1810/276524
dc.relation.replaces1810/276524
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBrain
dc.subjectNeural Pathways
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectBrain Mapping
dc.subjectRisk
dc.subjectReward
dc.subjectPsychotic Disorders
dc.subjectFemale
dc.subjectMale
dc.subjectYoung Adult
dc.subjectAnticipation, Psychological
dc.subjectProdromal Symptoms
dc.titleAbnormal reward prediction-error signalling in antipsychotic naive individuals with first-episode psychosis or clinical risk for psychosis.
dc.typeArticle
prism.endingPage1699
prism.issueIdentifier8
prism.publicationDate2018
prism.publicationNameNeuropsychopharmacology
prism.startingPage1691
prism.volume43
dc.identifier.doi10.17863/CAM.23822
dc.identifier.doi10.17863/CAM.30998
dcterms.dateAccepted2018-03-13
rioxxterms.versionofrecord10.1038/s41386-018-0056-2
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-07
dc.contributor.orcidErmakova, Anna O [0000-0002-1869-0084]
dc.contributor.orcidKnolle, Franziska [0000-0002-9542-613X]
dc.contributor.orcidBullmore, Edward [0000-0002-8955-8283]
dc.contributor.orcidJones, Peter [0000-0002-0387-880X]
dc.contributor.orcidRobbins, Trevor [0000-0003-0642-5977]
dc.contributor.orcidFletcher, Paul [0000-0001-8257-1517]
dc.contributor.orcidMurray, Graham [0000-0001-8296-1742]
dc.identifier.eissn1740-634X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (G1000183)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)
pubs.funder-project-idWellcome Trust (095692/Z/11/Z)
pubs.funder-project-idMedical Research Council (G0701911)
pubs.funder-project-idMedical Research Council (G0001354)
cam.issuedOnline2018-04-05
cam.orpheus.successThu Jan 30 13:00:30 GMT 2020 - The item has an open VoR version.
rioxxterms.freetoread.startdate2100-01-01


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International