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Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition.

Published version
Peer-reviewed

Type

Article

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Authors

Abstract

Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population. Organoid drug screening identified itraconazole perturbs dormancy through non-canonical hedgehog signalling effects on the WNT pathway.

Description

Keywords

cancer stem cell, cell cycle, colorectal cancer, dormancy, hedgehog, heterogeneity, itraconazole, plasticity, wnt

Journal Title

Mol Cell Oncol

Conference Name

Journal ISSN

2372-3556
2372-3556

Volume Title

5

Publisher

Informa UK Limited
Sponsorship
Cancer Research Uk (None)