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dc.contributor.authorHarris, Matthew
dc.contributor.authorSvensson, Fredrik
dc.contributor.authorKopanitsa, Liliya
dc.contributor.authorLadds, Graham
dc.contributor.authorBailey, David
dc.date.accessioned2018-10-18T10:22:14Z
dc.date.available2018-10-18T10:22:14Z
dc.identifier.issn1354-3776
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284150
dc.description.abstractGlioblastoma multiforme (GBM) is the most common and aggressive malignant glioma, with patients having a median survival of just over one year. Current chemotherapies, with surgery and radiotherapy, provide only minor patient benefit. There is a great need to discover and develop novel therapies for this devastating disease. Areas Covered: The patent literature reveals novel therapies, providing insights into emerging GBM therapeutics. We have used the Google and USPTO patent databases to generate a detailed landscape of patents and patent applications from companies active in the areas of glioma and/or GBM. Specific patents have been grouped into 6 areas: novel compounds; treatments and therapeutic targets; combination therapies; immunotherapies; delivery methods; and biomarkers for diagnosis and prognosis. Expert Opinion: There has been a steady increase in the number of patents on GBM over the last five years. Despite many new compounds being developed and patented for a broad range of cancers, only a small percentage of these are specifically targeted to GBM. Notable trends in the patent literature include both the development of combination therapies to combat the heterogeneous nature of GBM, and the use of immunotherapies building on the promise of cancer vaccines and CAR T-cell therapy.
dc.description.sponsorshipBBSRC
dc.publisherTaylor & Francis
dc.titleEmerging Patents in the Therapeutic Areas of Glioma and Glioblastoma.
dc.typeArticle
prism.publicationNameExpert Opinion on Therapeutic Patents
dc.identifier.doi10.17863/CAM.31521
dcterms.dateAccepted2018-06-25
rioxxterms.versionofrecord10.1080/13543776.2018.1494155.
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-06-25
dc.contributor.orcidHarris, Matthew [0000-0002-7918-5735]
dc.contributor.orcidSvensson, Fredrik [0000-0002-5556-8133]
dc.contributor.orcidLadds, Graham [0000-0001-7320-9612]
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (1643678)
cam.issuedOnline2018-06-27
rioxxterms.freetoread.startdate2019-06-28


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