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dc.contributor.authorFüllgrabe, Jens
dc.contributor.authorGhislat, Ghita
dc.contributor.authorCho, Dong-Hyung
dc.contributor.authorRubinsztein, David C
dc.date.accessioned2018-10-22T06:53:49Z
dc.date.available2018-10-22T06:53:49Z
dc.date.issued2016-08-15
dc.identifier.issn0021-9533
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284185
dc.description.abstractMacroautophagy, hereafter referred to as autophagy, is a catabolic process that results in the lysosomal degradation of cytoplasmic contents ranging from abnormal proteins to damaged cell organelles. It is activated  under diverse conditions, including nutrient deprivation and hypoxia. During autophagy, members of the core autophagy-related (ATG) family of proteins mediate membrane rearrangements, which lead to the engulfment and degradation of cytoplasmic cargo. Recently, the nuclear regulation of autophagy, especially by transcription factors and histone modifiers, has gained increased attention. These factors are not only involved in rapid responses to autophagic stimuli, but also regulate the long-term outcome of autophagy. Now there are more than 20 transcription factors that have been shown to be linked to the autophagic process. However, their interplay and timing appear enigmatic as several have been individually shown to act as major regulators of autophagy. This Cell Science at a Glance article and the accompanying poster highlights the main cellular regulators of transcription involved in mammalian autophagy and their target genes.
dc.format.mediumPrint
dc.languageeng
dc.publisherThe Company of Biologists
dc.subjectAnimals
dc.subjectMammals
dc.subjectHumans
dc.subjectTranscription Factors
dc.subjectSignal Transduction
dc.subjectCell Hypoxia
dc.subjectTranscription, Genetic
dc.subjectGene Expression Regulation
dc.subjectAutophagy
dc.titleTranscriptional regulation of mammalian autophagy at a glance.
dc.typeArticle
prism.endingPage3066
prism.issueIdentifier16
prism.publicationDate2016
prism.publicationNameJ Cell Sci
prism.startingPage3059
prism.volume129
dc.identifier.doi10.17863/CAM.31553
dcterms.dateAccepted2016-05-25
rioxxterms.versionofrecord10.1242/jcs.188920
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-08
dc.contributor.orcidRubinsztein, David C [0000-0001-5002-5263]
dc.identifier.eissn1477-9137
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (100140/Z/12/Z)
pubs.funder-project-idWellcome Trust (095317/Z/11/Z)
cam.issuedOnline2016-08-15
rioxxterms.freetoread.startdate2017-08-31


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