Cancer development: Origins in the oesophagus.
Authors
Zhuang, Lizhe
Fitzgerald, Rebecca C
Change log
Abstract
The cellular origins of a precancerous condition called Barrett's oesophagus have been unclear. Tracking and analysis of epithelial cells at the affected site could shed light on the problem. See Letter p.529
A precancerous condition called Barrett's oesophagus is of much interest, because it arises when some cells of the oesophagus take on a new identity — a phenomenon known as metaplasia. If we could understand where these altered cells come from, we might hold the key to preventing oesophageal cancer. On page 529, Jiang et al.1 provide fresh insight into the cell of origin for Barrett's oesophagus.
Publication Date
2017-10-26
Online Publication Date
2017-10-11
Acceptance Date
2017-10-04
Keywords
Adenocarcinoma, Esophageal Neoplasms, Humans
Journal Title
Nature
Journal ISSN
0028-0836
1476-4687
1476-4687
Volume Title
550
Publisher
Springer Science and Business Media LLC
Sponsorship
Medical Research Council (MC_UU_12022/2)