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dc.contributor.authorHockley, James
dc.contributor.authorSmith, Ewan
dc.contributor.authorBulmer, David
dc.date.accessioned2018-10-22T06:54:08Z
dc.date.available2018-10-22T06:54:08Z
dc.date.issued2018-10-01
dc.identifier.issn0193-1857
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284195
dc.description.abstractPeripheral sensitization of nociceptors during disease has long been recognized as a leading cause of inflammatory pain. However, a growing body of data generated over the last decade has led to the increased understanding that peripheral sensitization is also an important mechanism driving abdominal pain in highly prevalent functional bowel disorders, in particular, irritable bowel syndrome (IBS). As such, the development of drugs that target pain-sensing nerves innervating the bowel has the potential to be a successful analgesic strategy for the treatment of abdominal pain in both organic and functional gastrointestinal diseases. Despite the success of recent peripherally restricted approaches for the treatment of IBS, not all drugs that have shown efficacy in animal models of visceral pain have reduced pain end points in clinical trials of IBS patients, suggesting innate differences in the mechanisms of pain processing between rodents and humans and, in particular, how we model disease states. To address this gap in our understanding of peripheral nociception from the viscera and the body in general, several groups have developed experimental systems to study nociception in isolated human tissue and neurons, the findings of which we discuss in this review. Studies of human tissue identify a repertoire of human primary afferent subtypes comparable to rodent models including a nociceptor population, the targeting of which will shape future analgesic development efforts. Detailed mechanistic studies in human sensory neurons combined with unbiased RNA-sequencing approaches have revealed fundamental differences in not only receptor/channel expression but also peripheral pain pathways.
dc.description.sponsorshipNone
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherAmerican Physiological Society
dc.subjectIntestines
dc.subjectGanglia, Spinal
dc.subjectNociceptors
dc.subjectAnimals
dc.subjectHumans
dc.subjectIrritable Bowel Syndrome
dc.subjectTranslational Medical Research
dc.subjectNociception
dc.titleHuman visceral nociception: findings from translational studies in human tissue.
dc.typeArticle
prism.endingPageG472
prism.issueIdentifier4
prism.publicationDate2018
prism.publicationNameAm J Physiol Gastrointest Liver Physiol
prism.startingPageG464
prism.volume315
dc.identifier.doi10.17863/CAM.31563
dcterms.dateAccepted2018-05-25
rioxxterms.versionofrecord10.1152/ajpgi.00398.2017
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-10
dc.contributor.orcidHockley, James [0000-0002-9578-6071]
dc.contributor.orcidSmith, Ewan [0000-0002-2699-1979]
dc.contributor.orcidBulmer, David [0000-0002-4703-7877]
dc.identifier.eissn1522-1547
rioxxterms.typeJournal Article/Review
pubs.funder-project-idRosetrees Trust (A1296)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/R006210/1)
cam.issuedOnline2018-05-31
rioxxterms.freetoread.startdate2019-10-31


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