Lipid metabolism in terminal erythropoiesis.
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Authors
Gibson, John S
Rees, David C
Publication Date
2018-06-28Journal Title
Blood
ISSN
0006-4971
Publisher
American Society of Hematology
Volume
131
Issue
26
Pages
2872-2874
Language
eng
Type
Article
Metadata
Show full item recordCitation
Gibson, J. S., & Rees, D. C. (2018). Lipid metabolism in terminal erythropoiesis.. Blood, 131 (26), 2872-2874. https://doi.org/10.1182/blood-2018-05-850255
Abstract
In this issue of Blood, Huang et al have provided evidence that altered lipid metabolism is critical for terminal erythropoiesis. A key role is proposed for the PHOSPHO1 gene product, a phosphocholine phosphatase. PHOSPHO1 knockouts (KOs) showed reduced erythroblast proliferation and enucleation in both mice and human erythroid tissues, apparently through energy depletion mediated via inhibition of oxidative phosphorylation of fatty acids and reduced adenosine triphosphate (ATP) production in late glycolysis. This work emphasizes that altered expression of genes involving lipid metabolism are important during late red cell maturation.
Keywords
Erythropoiesis, Lipid Metabolism, Phosphorylcholine
Sponsorship
British Heart Foundation (PG/15/118/31966)
Identifiers
External DOI: https://doi.org/10.1182/blood-2018-05-850255
This record's URL: https://www.repository.cam.ac.uk/handle/1810/284204
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http://www.rioxx.net/licenses/all-rights-reserved
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