Show simple item record

dc.contributor.authorGibson, John
dc.contributor.authorRees, David C
dc.date.accessioned2018-10-22T06:54:24Z
dc.date.available2018-10-22T06:54:24Z
dc.date.issued2018-06-28
dc.identifier.issn0006-4971
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284204
dc.description.abstractIn this issue of Blood, Huang et al have provided evidence that altered lipid metabolism is critical for terminal erythropoiesis. A key role is proposed for the PHOSPHO1 gene product, a phosphocholine phosphatase. PHOSPHO1 knockouts (KOs) showed reduced erythroblast proliferation and enucleation in both mice and human erythroid tissues, apparently through energy depletion mediated via inhibition of oxidative phosphorylation of fatty acids and reduced adenosine triphosphate (ATP) production in late glycolysis. This work emphasizes that altered expression of genes involving lipid metabolism are important during late red cell maturation.
dc.languageeng
dc.publisherAmerican Society of Hematology
dc.titleLipid metabolism in terminal erythropoiesis.
dc.typeArticle
prism.endingPage2874
prism.issueIdentifier26
prism.publicationNameBlood
prism.startingPage2872
prism.volume131
dc.identifier.doi10.17863/CAM.31572
rioxxterms.versionofrecord10.1182/blood-2018-05-850255
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.contributor.orcidGibson, John [0000-0001-6145-9139]
dc.identifier.eissn1528-0020
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBritish Heart Foundation (PG/15/118/31966)
cam.issuedOnline2018-06-28
rioxxterms.freetoread.startdate2019-06-28


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record