© 2014 by Wiley-VCH Verlag GmbH & Co. KGaA. Synchronization of two dissipatively coupled Van der Pol oscillators in the quantum regime is studied. Due to quantum noise strict frequency locking is absent and is replaced by a crossover from weak to strong frequency entrainment. The differences to the behavior of one quantum Van der Pol oscillator subject to an external drive are discussed. Moreover, a possible experimental realization of two coupled quantum Van der Pol oscillators in an optomechanical setting is described.