On the origin of the human germline.
The Company of Biologists
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Kobayashi, T., & Surani, A. (2018). On the origin of the human germline.. Development, 145 (16) https://doi.org/10.1242/dev.150433
In mice, primordial germ cells (PGCs), the precursors of eggs and sperm, originate from pregastrulation postimplantation embryos. By contrast, the origin of human PGCs (hPGCs) has been less clear and has been difficult to study because of the technical and ethical constraints that limit direct studies on human embryos. In recent years, however, in vitro simulation models using human pluripotent stem cells, together with surrogate non-rodent mammalian embryos, have provided insights and experimental approaches to address this issue. Here, we review these studies, which suggest that the posterior epiblast and/or the nascent amnion in pregastrulation human embryos is a likely source of hPGCs, and that a different gene regulatory network controls PGCs in humans compared with in the mouse. Such studies on the origins and mechanisms of hPGC specification prompt further consideration of the somatic cell fate decisions that occur during early human development.
Germ Cells, Pluripotent Stem Cells, Germ Layers, Animals, Humans, Mice, Cell Differentiation, Epigenesis, Genetic, Embryonic Development, Embryonic Stem Cells, Gene Regulatory Networks, Embryo, Mammalian, Human Embryonic Stem Cells
Wellcome Trust (096738/Z/11/Z)
Medical Research Council (MR/P009948/1)
External DOI: https://doi.org/10.1242/dev.150433
This record's URL: https://www.repository.cam.ac.uk/handle/1810/284494