Quality of life outcomes in patients with localised renal cancer: a literature review.
World journal of urology
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Rossi, S., Klatte, T., & Stewart, G. (2018). Quality of life outcomes in patients with localised renal cancer: a literature review.. World journal of urology, 36 (12), 1961-1972. https://doi.org/10.1007/s00345-018-2415-3
Purpose: Patients with localised renal cell carcinoma (RCC) can expect excellent oncologic outcomes. As such, there has been a shift towards maximising health related quality of life (HRQoL). A greater understanding of HRQoL outcomes associated with different management options for RCC can facilitate patient centred care, shared decision making and enable cost utility analyses to guide health policies. The aim of this literature review was to evaluate the evidence regarding HRQoL outcomes after interventions for localised RCC. Methods: Three databases were searched to identify studies reporting HRQoL in patients with localised renal cancer, including Medline, the Tuft’s Medical Centre Cost Effectiveness Analysis registry and the EuroQol website. Results: Considerable methodological heterogeneity was noted. Laparoscopic nephrectomy was associated with significantly better short term physical function compared to open surgery, although the effect on mental function was inconclusive. Nephron-sparing surgery was associated with better physical function compared to radical surgery. Patients’ perception of remaining renal function was a significant independent predictor of HRQoL, rather than surgery type. Tumour size, stage, post-operative complications, age, body mass index, occupational status, educational level and co-morbidities were significant predictors of HRQoL. Only three studies were available regarding non-surgical management options and very little data was available regarding the impact of follow up protocols and long-term effects of “cancer survivorship.” Conclusion: There is a need for validated and reproducible RCC specific HRQoL instruments and standardisation amongst studies to enable comparisons. Increased awareness regarding determinants of poor HRQoL may enable high risk patients to receive tailored support.
Nephrons, Humans, Carcinoma, Renal Cell, Kidney Neoplasms, Postoperative Complications, Neoplasm Staging, Body Mass Index, Nephrectomy, Tumor Burden, Decision Making, Age Factors, Comorbidity, Health Status, Quality of Life, Health Policy, Educational Status, Employment, Cost-Benefit Analysis, Patient-Centered Care, Organ Sparing Treatments, Patient Reported Outcome Measures
The urology foundation
Urology Foundation (unknown)
External DOI: https://doi.org/10.1007/s00345-018-2415-3
This record's URL: https://www.repository.cam.ac.uk/handle/1810/284523
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/