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dc.contributor.authorRossi, Sabrinaen
dc.contributor.authorKlatte, Tobiasen
dc.contributor.authorStewart, Granten
dc.date.accessioned2018-11-01T14:03:36Z
dc.date.available2018-11-01T14:03:36Z
dc.date.issued2018-12en
dc.identifier.issn0724-4983
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284523
dc.description.abstractPurpose: Patients with localised renal cell carcinoma (RCC) can expect excellent oncologic outcomes. As such, there has been a shift towards maximising health related quality of life (HRQoL). A greater understanding of HRQoL outcomes associated with different management options for RCC can facilitate patient centred care, shared decision making and enable cost utility analyses to guide health policies. The aim of this literature review was to evaluate the evidence regarding HRQoL outcomes after interventions for localised RCC. Methods: Three databases were searched to identify studies reporting HRQoL in patients with localised renal cancer, including Medline, the Tuft’s Medical Centre Cost Effectiveness Analysis registry and the EuroQol website. Results: Considerable methodological heterogeneity was noted. Laparoscopic nephrectomy was associated with significantly better short term physical function compared to open surgery, although the effect on mental function was inconclusive. Nephron-sparing surgery was associated with better physical function compared to radical surgery. Patients’ perception of remaining renal function was a significant independent predictor of HRQoL, rather than surgery type. Tumour size, stage, post-operative complications, age, body mass index, occupational status, educational level and co-morbidities were significant predictors of HRQoL. Only three studies were available regarding non-surgical management options and very little data was available regarding the impact of follow up protocols and long-term effects of “cancer survivorship.” Conclusion: There is a need for validated and reproducible RCC specific HRQoL instruments and standardisation amongst studies to enable comparisons. Increased awareness regarding determinants of poor HRQoL may enable high risk patients to receive tailored support.
dc.description.sponsorshipThe urology foundation
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherSpringer Nature
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectNephronsen
dc.subjectHumansen
dc.subjectCarcinoma, Renal Cellen
dc.subjectKidney Neoplasmsen
dc.subjectPostoperative Complicationsen
dc.subjectNeoplasm Stagingen
dc.subjectBody Mass Indexen
dc.subjectNephrectomyen
dc.subjectTumor Burdenen
dc.subjectDecision Makingen
dc.subjectAge Factorsen
dc.subjectComorbidityen
dc.subjectHealth Statusen
dc.subjectQuality of Lifeen
dc.subjectHealth Policyen
dc.subjectEducational Statusen
dc.subjectEmploymenten
dc.subjectCost-Benefit Analysisen
dc.subjectPatient-Centered Careen
dc.subjectOrgan Sparing Treatmentsen
dc.subjectPatient Reported Outcome Measuresen
dc.titleQuality of life outcomes in patients with localised renal cancer: a literature review.en
dc.typeArticle
prism.endingPage1972
prism.issueIdentifier12en
prism.publicationDate2018en
prism.publicationNameWorld journal of urologyen
prism.startingPage1961
prism.volume36en
dc.identifier.doi10.17863/CAM.31898
dcterms.dateAccepted2018-07-18en
rioxxterms.versionofrecord10.1007/s00345-018-2415-3en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-12en
dc.contributor.orcidRossi, Sabrina [0000-0001-7048-7158]
dc.contributor.orcidKlatte, Tobias [0000-0002-4392-6861]
dc.contributor.orcidStewart, Grant [0000-0003-3188-9140]
dc.identifier.eissn1433-8726
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idUrology Foundation (unknown)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International