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dc.contributor.authorBoulenouar, Selma
dc.contributor.authorDoisne, Jean-Marc
dc.contributor.authorSferruzzi-Perri, Amanda
dc.contributor.authorGaynor, Louise M
dc.contributor.authorKieckbusch, Jens
dc.contributor.authorBalmas, Elisa
dc.contributor.authorYung, Billy
dc.contributor.authorJavadzadeh, Shagayegh
dc.contributor.authorVolmer, Léa
dc.contributor.authorHawkes, Delia A
dc.contributor.authorPhillips, Keli
dc.contributor.authorBrady, Hugh JM
dc.contributor.authorFowden, Abigail
dc.contributor.authorBurton, Graham
dc.contributor.authorMoffett, Ashley
dc.contributor.authorColucci, Francesco
dc.date.accessioned2018-11-01T14:03:51Z
dc.date.available2018-11-01T14:03:51Z
dc.date.issued2016
dc.identifier.issn1664-3224
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284530
dc.description.abstractUterine NK cells are innate lymphoid cells (ILC) that populate the uterus and expand during pregnancy, regulating placental development and fetal growth in humans and mice. We have recently characterized the composition of uterine ILCs (uILCs), some of which require the transcription factor NFIL3, but the extent to which NFIL3-dependent cells support successful reproduction in mice is unknown. By mating Nfil3 (-/-) females with wild-type males, here we show the effects of NFIL3 deficiency in maternal cells on both the changes in uILCs during pregnancy and the downstream consequences on reproduction. Despite the presence of CD49a(+)Eomes(-) uILC1s and the considerable expansion of residual CD49a(+)Eomes(+) tissue-resident NK cells and uILC3s in pregnant Nfil3 (-/-) mice, we found incomplete remodeling of uterine arteries and decidua, placental defects, and fetal growth restriction in litters of normal size. These results show that maternal NFIL3 mediates non-redundant functions in mouse reproduction.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherFrontiers Media SA
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe Residual Innate Lymphoid Cells in NFIL3-Deficient Mice Support Suboptimal Maternal Adaptations to Pregnancy.
dc.typeArticle
prism.publicationDate2016
prism.publicationNameFront Immunol
prism.startingPage43
prism.volume7
dc.identifier.doi10.17863/CAM.31905
dcterms.dateAccepted2016-01-29
rioxxterms.versionofrecord10.3389/fimmu.2016.00043
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-01
dc.contributor.orcidSferruzzi-Perri, Amanda [0000-0002-4931-4233]
dc.contributor.orcidKieckbusch, Jens [0000-0002-5930-1575]
dc.contributor.orcidYung, Billy [0000-0002-0869-7426]
dc.contributor.orcidFowden, Abigail [0000-0002-3384-4467]
dc.contributor.orcidBurton, Graham [0000-0001-8677-4143]
dc.contributor.orcidMoffett, Ashley [0000-0002-8388-9073]
dc.contributor.orcidColucci, Francesco [0000-0001-5193-6376]
dc.identifier.eissn1664-3224
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (094073/Z/10/Z)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idBritish Heart Foundation (None)
cam.issuedOnline2016-02-19


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International