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dc.contributor.authorWang, Jiazheng
dc.contributor.authorHesketh, Richard L
dc.contributor.authorWright, Alan J
dc.contributor.authorBrindle, Kevin M
dc.date.accessioned2018-11-05T10:26:03Z
dc.date.available2018-11-05T10:26:03Z
dc.date.issued2018-11
dc.identifier.issn0952-3480
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284610
dc.description.abstractHyperpolarized MRI with 13 C-labeled metabolites has enabled metabolic imaging of tumors in vivo. The heterogeneous nature of tumors and the limited lifetime of the hyperpolarization require high resolution, both temporally and spatially. We describe two sequences that make more efficient use of the 13 C polarization than previously described single-shot 3D sequences. With these sequences, the target metabolite resonances were excited using spectral-spatial pulses and the data acquired using spiral readouts from a series of echoes created using a fast-spin-echo sequence employing adiabatic 180° pulses. The third dimension was encoded with blipped gradients applied in an interleaved order to the echo train. Adiabatic inversion pulses applied in the absence of slice selection gradients allowed acquisition of signal from odd echoes, formed by unpaired adiabatic pulses, as well as from even echoes. The sequences were tested on tumor-bearing mice following intravenous injection of hyperpolarized [1-13 C]pyruvate. [1-13 C] pyruvate and [1-13 C] lactate images were acquired in vivo with a 4 × 4 × 2 cm3 field of view and a 32 × 32 × 16 matrix, leading to a nominal resolution of 1.25 × 1.25 × 1.25 mm3 and an effective resolution of 1.25 × 1.25 × 4.5 mm3 when the z-direction point spread function was taken into account. The acquisition of signal from more echoes also allowed for an improvement in the signal-to-noise ratio for resonances with longer T2 relaxation times. The pulse sequences described here produced hyperpolarized 13 C images with improved resolution and signal-to-noise ratio when compared with similar sequences described previously.
dc.description.sponsorshipCancer Research UK Programme grant (17242) to KMB and by the CRUK-EPSRC Imaging Centre in Cambridge and Manchester (16465). JW as in part supported by supported, in part, by a grant from the Danish Strategic Research Council (LIFE-DNP: Hyperpolarized magnetic resonance for in vivo quantification of lipid, sugar and amino acid metabolism in lifestyle related diseases).
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherWiley
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAnimals
dc.subjectMice
dc.subjectLactic Acid
dc.subjectPyruvic Acid
dc.subjectSpin Labels
dc.subjectImaging, Three-Dimensional
dc.subjectPhantoms, Imaging
dc.subjectAlgorithms
dc.subjectSignal Processing, Computer-Assisted
dc.subjectCarbon-13 Magnetic Resonance Spectroscopy
dc.titleHyperpolarized 13 C spectroscopic imaging using single-shot 3D sequences with unpaired adiabatic refocusing pulses.
dc.typeArticle
prism.issueIdentifier11
prism.publicationDate2018
prism.publicationNameNMR Biomed
prism.startingPagee4004
prism.volume31
dc.identifier.doi10.17863/CAM.31984
dcterms.dateAccepted2018-07-10
rioxxterms.versionofrecord10.1002/nbm.4004
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-11
dc.contributor.orcidWang, Jiazheng [0000-0003-1182-442X]
dc.contributor.orcidWright, Alan J [0000-0002-4577-5681]
dc.contributor.orcidBrindle, Kevin M [0000-0003-3883-6287]
dc.identifier.eissn1099-1492
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCancer Research UK (CB4100)
pubs.funder-project-idAarhus University (Source: Data Science Research Centre (DSRC)) (15952)
pubs.funder-project-idCancer Research Uk (None)
cam.issuedOnline2018-09-10


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International