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dc.contributor.authorTran, Maxine GBen
dc.contributor.authorSut, Michal Ken
dc.contributor.authorCollie, Janeen
dc.contributor.authorNeves, Joana Ben
dc.contributor.authorAl-Hayek, Samihen
dc.contributor.authorArmitage, James Nen
dc.contributor.authorCouturier, Dominiqueen
dc.contributor.authorWiseman, Oliver Jen
dc.date.accessioned2018-11-06T11:58:39Z
dc.date.available2018-11-06T11:58:39Z
dc.date.issued2018-06en
dc.identifier.issn0892-7790
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284649
dc.description.abstractINTRODUCTION: Patient reported outcome measures (PROMs) are powerful instruments to assess the impact of a disease on health from the patient's perspective. We describe the process of designing, testing, and validating the Cambridge Ureteral Stone PROM (CUSP). MATERIALS AND METHODS: Patients recently diagnosed with ureteral stones were approached for participation in focus groups, structured interviews, and test-retest validation studies. Statistical tests included Cronbach's alpha for internal consistency, Spearman's and Pearson's correlation coefficients for test-retest validity, permutation tests of equality of means and Spearman's correlation coefficients for discriminant validity. RESULTS: Forty-three patients participated in the development of the CUSP. Twenty-two patients were involved in the focus groups and structured interviews and a further 21 participated in the prospective test-retest study. Expressed comments were grouped into seven broad health domains: pain, fatigue, sleep disturbance, work and daily activities, anxiety, gastrointestinal (GI) symptoms, and urinary symptoms. Items were selected from established PROM platforms to form the draft (dCUSP) instrument, which was then used for test-retest validation and item reduction. All domains scored highly for Cronbach's alpha (>0.8), with the exception of GI symptoms. Large Spearman's (>0.76) and Pearson's correlation estimates (>0.83) were obtained for test-retest validity, suggesting that answers were reliable through the time period tested. The estimates of the Spearman's correlation coefficient between each pair of domains ranged from 0.17 to 0.78 and the upper bounds of the corresponding 95% confidence intervals were all smaller than 0.95, suggesting that each domain measures something different. The tests of equality of the mean of scores of the control (n = 25) and patient groups were all significant, suggesting that CUSP successfully discriminated patients suffering from ureteral stones for every domain. CONCLUSION: CUSP is a patient-derived ureteral stone PROM, which can be used to measure ureteral stone disease health outcomes from the patient's point of view.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.subjectHumansen
dc.subjectGastrointestinal Diseasesen
dc.subjectPainen
dc.subjectSleep Initiation and Maintenance Disordersen
dc.subjectUreteral Calculien
dc.subjectFatigueen
dc.subjectActivities of Daily Livingen
dc.subjectFocus Groupsen
dc.subjectProspective Studiesen
dc.subjectReproducibility of Resultsen
dc.subjectAnxietyen
dc.subjectQuality of Lifeen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectUrinary Bladder Diseasesen
dc.subjectSurveys and Questionnairesen
dc.subjectPatient Reported Outcome Measuresen
dc.titleDevelopment of a Disease-Specific Ureteral Calculus Patient Reported Outcome Measurement Instrument.en
dc.typeArticle
prism.endingPage558
prism.issueIdentifier6en
prism.publicationDate2018en
prism.publicationNameJournal of endourologyen
prism.startingPage548
prism.volume32en
dc.identifier.doi10.17863/CAM.32023
dcterms.dateAccepted2018-03-07en
rioxxterms.versionofrecord10.1089/end.2017.0795en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-06en
dc.contributor.orcidTran, Maxine GB [0000-0002-6034-4433]
dc.contributor.orcidNeves, Joana B [0000-0002-8578-9893]
dc.contributor.orcidCouturier, Dominique-Laurent [0000-0001-5774-5036]
dc.identifier.eissn1557-900X
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2019-04-09


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