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dc.contributor.authorBayraktar, Gonca
dc.contributor.authorKreutz, Michael R
dc.date.accessioned2018-11-07T00:30:35Z
dc.date.available2018-11-07T00:30:35Z
dc.date.issued2018
dc.identifier.issn1662-5099
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284685
dc.description.abstractOver the last decade, an increasing number of reports underscored the importance of epigenetic regulations in brain plasticity. Epigenetic elements such as readers, writers and erasers recognize, establish, and remove the epigenetic tags in nucleosomes, respectively. One such regulation concerns DNA-methylation and demethylation, which are highly dynamic and activity-dependent processes even in the adult neurons. It is nowadays widely believed that external stimuli control the methylation marks on the DNA and that such processes serve transcriptional regulation in neurons. In this mini-review, we cover the current knowledge on the regulatory mechanisms controlling in particular DNA demethylation as well as the possible functional consequences in health and disease.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherFrontiers Media SA
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders.
dc.typeArticle
prism.publicationDate2018
prism.publicationNameFront Mol Neurosci
prism.startingPage169
prism.volume11
dc.identifier.doi10.17863/CAM.32058
dcterms.dateAccepted2018-05-04
rioxxterms.versionofrecord10.3389/fnmol.2018.00169
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-01
dc.contributor.orcidBayraktar, Gonca [0000-0001-5476-4346]
dc.identifier.eissn1662-5099
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-05-23


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International