Neurodevelopmental Impairment in Children After Group B Streptococcal Disease Worldwide: Systematic Review and Meta-analyses.
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Authors
Kohli-Lynch, Maya
Russell, Neal J
Seale, Anna C
Dangor, Ziyaad
Tann, Cally J
Baker, Carol J
Bartlett, Linda
Cutland, Clare
Gravett, Michael G
Heath, Paul T
Ip, Margaret
Le Doare, Kirsty
Madhi, Shabir A
Rubens, Craig E
Saha, Samir K
Schrag, Stephanie
Sobanjo-Ter Meulen, Ajoke
Vekemans, Johan
O'Sullivan, Catherine
Nakwa, Firdose
Ben Hamouda, Hechmi
Soua, Habib
Giorgakoudi, Kyriaki
Ladhani, Shamez
Lamagni, Theresa
Rattue, Hilary
Lawn, Joy E
Publication Date
2017-11-06Journal Title
Clin Infect Dis
ISSN
1058-4838
Publisher
Oxford University Press (OUP)
Volume
65
Issue
suppl_2
Pages
S190-S199
Language
eng
Type
Article
Physical Medium
Print
Metadata
Show full item recordCitation
Kohli-Lynch, M., Russell, N. J., Seale, A. C., Dangor, Z., Tann, C. J., Baker, C. J., Bartlett, L., et al. (2017). Neurodevelopmental Impairment in Children After Group B Streptococcal Disease Worldwide: Systematic Review and Meta-analyses.. Clin Infect Dis, 65 (suppl_2), S190-S199. https://doi.org/10.1093/cid/cix663
Abstract
BACKGROUND: Survivors of infant group B streptococcal (GBS) disease are at risk of neurodevelopmental impairment (NDI), a burden not previously systematically quantified. This is the 10th of 11 articles estimating the burden of GBS disease. Here we aimed to estimate NDI in survivors of infant GBS disease. METHODS: We conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data on the risk of NDI after invasive GBS disease in infants <90 days of age. We did meta-analyses to derive pooled estimates of the percentage of infants with NDI following GBS meningitis. RESULTS: We identified 6127 studies, of which 18 met eligibility criteria, all from middle- or high-income contexts. All 18 studies followed up survivors of GBS meningitis; only 5 of these studies also followed up survivors of GBS sepsis and were too few to pool in a meta-analysis. Of meningitis survivors, 32% (95% CI, 25%-38%) had NDI at 18 months of follow-up, including 18% (95% CI, 13%-22%) with moderate to severe NDI. CONCLUSIONS: GBS meningitis is an important risk factor for moderate to severe NDI, affecting around 1 in 5 survivors. However, data are limited, and we were unable to estimate NDI after GBS sepsis. Comparability of studies is difficult due to methodological differences including variability in timing of clinical reviews and assessment tools. Follow-up of clinical cases and standardization of methods are essential to fully quantify the total burden of NDI associated with GBS disease, and inform program priorities.
Keywords
Humans, Streptococcus agalactiae, Meningitis, Bacterial, Streptococcal Infections, Risk Factors, Developmental Disabilities, Infant, Global Health
Sponsorship
Meningitis Research Foundation (CH/LG/GC 13020)
Identifiers
External DOI: https://doi.org/10.1093/cid/cix663
This record's URL: https://www.repository.cam.ac.uk/handle/1810/284946
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