Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease.
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Authors
Teo, Shu Mei
Mok, Danny
Judd, Louise M
Watts, Stephen C
Pham, Kym
Holt, Barbara J
Kusel, Merci
Serralha, Michael
Troy, Niamh
Bochkov, Yury A
Grindle, Kristine
Lemanske, Robert F
Johnston, Sebastian L
Gern, James E
Sly, Peter D
Holt, Patrick G
Holt, Kathryn E
Publication Date
2018-09-12Journal Title
Cell Host Microbe
ISSN
1931-3128
Publisher
Elsevier BV
Volume
24
Issue
3
Pages
341-352.e5
Language
eng
Type
Article
Physical Medium
Print
Metadata
Show full item recordCitation
Teo, S. M., Tang, H., Mok, D., Judd, L. M., Watts, S. C., Pham, K., Holt, B. J., et al. (2018). Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease.. Cell Host Microbe, 24 (3), 341-352.e5. https://doi.org/10.1016/j.chom.2018.08.005
Abstract
Repeated cycles of infection-associated lower airway inflammation drive the pathogenesis of persistent wheezing disease in children. In this study, the occurrence of acute respiratory tract illnesses (ARIs) and the nasopharyngeal microbiome (NPM) were characterized in 244 infants through their first five years of life. Through this analysis, we demonstrate that >80% of infectious events involve viral pathogens, but are accompanied by a shift in the NPM toward dominance by a small range of pathogenic bacterial genera. Unexpectedly, this change frequently precedes the detection of viral pathogens and acute symptoms. Colonization of illness-associated bacteria coupled with early allergic sensitization is associated with persistent wheeze in school-aged children, which is the hallmark of the asthma phenotype. In contrast, these bacterial genera are associated with "transient wheeze" that resolves after age 3 years in non-sensitized children. Thus, to complement early allergic sensitization, monitoring NPM composition may enable early detection and intervention in high-risk children.
Keywords
Nasopharynx, Humans, Respiratory Tract Infections, Asthma, Hypersensitivity, Acute Disease, Disease Susceptibility, Respiratory Sounds, Immunoglobulin E, Risk Factors, Cohort Studies, Longitudinal Studies, Prospective Studies, Child, Preschool, Infant, Female, Male, Microbiota
Sponsorship
Medical Research Council (MR/L003120/1)
British Heart Foundation (None)
Identifiers
External DOI: https://doi.org/10.1016/j.chom.2018.08.005
This record's URL: https://www.repository.cam.ac.uk/handle/1810/284950
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