Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease.
View / Open Files
Authors
Teo, Shu Mei
Tang, Howard HF
Mok, Danny
Judd, Louise M
Watts, Stephen C
Pham, Kym
Holt, Barbara J
Kusel, Merci
Serralha, Michael
Troy, Niamh
Bochkov, Yury A
Grindle, Kristine
Lemanske, Robert F
Johnston, Sebastian L
Gern, James E
Sly, Peter D
Holt, Patrick G
Holt, Kathryn E
Publication Date
2018-09-12Journal Title
Cell Host Microbe
ISSN
1931-3128
Publisher
Elsevier BV
Volume
24
Issue
3
Pages
341-352.e5
Language
eng
Type
Article
Physical Medium
Print
Metadata
Show full item recordCitation
Teo, S. M., Tang, H. H., Mok, D., Judd, L. M., Watts, S. C., Pham, K., Holt, B. J., et al. (2018). Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease.. Cell Host Microbe, 24 (3), 341-352.e5. https://doi.org/10.1016/j.chom.2018.08.005
Abstract
Repeated cycles of infection-associated lower airway inflammation drive the pathogenesis of persistent wheezing disease in children. In this study, the occurrence of acute respiratory tract illnesses (ARIs) and the nasopharyngeal microbiome (NPM) were characterized in 244 infants through their first five years of life. Through this analysis, we demonstrate that >80% of infectious events involve viral pathogens, but are accompanied by a shift in the NPM toward dominance by a small range of pathogenic bacterial genera. Unexpectedly, this change frequently precedes the detection of viral pathogens and acute symptoms. Colonization of illness-associated bacteria coupled with early allergic sensitization is associated with persistent wheeze in school-aged children, which is the hallmark of the asthma phenotype. In contrast, these bacterial genera are associated with "transient wheeze" that resolves after age 3 years in non-sensitized children. Thus, to complement early allergic sensitization, monitoring NPM composition may enable early detection and intervention in high-risk children.
Keywords
airway microbiota, allergic sensitization, asthma, lower respiratory infection, Acute Disease, Asthma, Child, Preschool, Cohort Studies, Disease Susceptibility, Female, Humans, Hypersensitivity, Immunoglobulin E, Infant, Longitudinal Studies, Male, Microbiota, Nasopharynx, Prospective Studies, Respiratory Sounds, Respiratory Tract Infections, Risk Factors
Sponsorship
Medical Research Council (MR/L003120/1)
British Heart Foundation (None)
Identifiers
External DOI: https://doi.org/10.1016/j.chom.2018.08.005
This record's URL: https://www.repository.cam.ac.uk/handle/1810/284950
Rights
Licence:
http://www.rioxx.net/licenses/all-rights-reserved
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: support@repository.cam.ac.uk